Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yjhX-yjhQ/YjhX-GNAT
Location 4174876..4175690 Replicon chromosome
Accession NZ_CP098231
Organism Escherichia coli strain XJ34

Toxin (Protein)


Gene name yjhX Uniprot ID S1PA82
Locus tag KFZ60_RS20125 Protein ID WP_001054376.1
Coordinates 4174876..4175133 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name yjhQ Uniprot ID -
Locus tag KFZ60_RS20130 Protein ID WP_088375732.1
Coordinates 4175145..4175690 (+) Length 182 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KFZ60_RS20100 (4170164) 4170164..4171270 + 1107 WP_001309184.1 N-acetylneuraminate epimerase -
KFZ60_RS20105 (4171335) 4171335..4172315 + 981 WP_000991438.1 9-O-acetyl-N-acetylneuraminic acid deacetylase -
KFZ60_RS20110 (4172425) 4172425..4172630 + 206 Protein_3936 HNH endonuclease -
KFZ60_RS20115 (4172898) 4172898..4174138 - 1241 Protein_3937 helicase YjhR -
KFZ60_RS20120 (4174254) 4174254..4174385 + 132 WP_001309182.1 hypothetical protein -
KFZ60_RS20125 (4174876) 4174876..4175133 + 258 WP_001054376.1 YjhX family toxin Toxin
KFZ60_RS20130 (4175145) 4175145..4175690 + 546 WP_088375732.1 N-acetyltransferase Antitoxin
KFZ60_RS20135 (4175746) 4175746..4176492 + 747 WP_000354251.1 class I SAM-dependent methyltransferase -
KFZ60_RS20140 (4176661) 4176661..4176879 + 219 Protein_3942 hypothetical protein -
KFZ60_RS20145 (4176917) 4176917..4177033 + 117 Protein_3943 VOC family protein -
KFZ60_RS20150 (4177278) 4177278..4178399 + 1122 WP_000010829.1 M42 family metallopeptidase -
KFZ60_RS20155 (4178396) 4178396..4178674 + 279 WP_000722973.1 PTS sugar transporter subunit IIB SgcB -
KFZ60_RS20160 (4178686) 4178686..4179999 + 1314 WP_000460843.1 PTS sugar transporter subunit IIC SgcC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - fimI / fimA / fimE / fimB 4164662..4183914 19252


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Putative toxin of bacterial toxin-antitoxin pair

(1-85)

Antitoxin

GNAT domain

(18-121)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9734.29 Da        Isoelectric Point: 11.0090

>T247310 WP_001054376.1 NZ_CP098231:4174876-4175133 [Escherichia coli]
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTELNKVRA
QLDNR

Download         Length: 258 bp

Antitoxin


Download         Length: 182 a.a.        Molecular weight: 19926.87 Da        Isoelectric Point: 6.3277

>AT247310 WP_088375732.1 NZ_CP098231:4175145-4175690 [Escherichia coli]
MTVHHFTFHITDKSDASDIREVETRAFGFSKEADLVASLLEDESARPALSLLARYEGKAVGHILFTRAAFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCADPDETGALT

Download         Length: 546 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PA82

Antitoxin

Source ID Structure

References