Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | ccdAB/CcdA(antitoxin) |
Location | 4006656..4007206 | Replicon | chromosome |
Accession | NZ_CP098231 | ||
Organism | Escherichia coli strain XJ34 |
Toxin (Protein)
Gene name | ccdB | Uniprot ID | Q32K46 |
Locus tag | KFZ60_RS19340 | Protein ID | WP_001160974.1 |
Coordinates | 4006656..4006970 (-) | Length | 105 a.a. |
Antitoxin (Protein)
Gene name | ccdA | Uniprot ID | V0VEX8 |
Locus tag | KFZ60_RS19345 | Protein ID | WP_000125566.1 |
Coordinates | 4006973..4007206 (-) | Length | 78 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
KFZ60_RS19315 (4002331) | 4002331..4003617 | + | 1287 | WP_000800457.1 | peptidylprolyl isomerase SurA | - |
KFZ60_RS19320 (4003617) | 4003617..4004606 | + | 990 | WP_075331727.1 | 4-hydroxythreonine-4-phosphate dehydrogenase PdxA | - |
KFZ60_RS19325 (4004603) | 4004603..4005424 | + | 822 | WP_001065381.1 | 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))- dimethyltransferase RsmA | - |
KFZ60_RS19330 (4005427) | 4005427..4005804 | + | 378 | WP_000610901.1 | Co2+/Mg2+ efflux protein ApaG | - |
KFZ60_RS19335 (4005811) | 4005811..4006659 | + | 849 | WP_000257188.1 | bis(5'-nucleosyl)-tetraphosphatase (symmetrical) ApaH | - |
KFZ60_RS19340 (4006656) | 4006656..4006970 | - | 315 | WP_001160974.1 | CcdB family protein | Toxin |
KFZ60_RS19345 (4006973) | 4006973..4007206 | - | 234 | WP_000125566.1 | type II toxin-antitoxin system CcdA family antitoxin | Antitoxin |
KFZ60_RS19350 (4007292) | 4007292..4007771 | - | 480 | WP_000624375.1 | type 3 dihydrofolate reductase | - |
KFZ60_RS19355 (4007963) | 4007963..4009825 | - | 1863 | WP_097755997.1 | glutathione-regulated potassium-efflux system protein KefC | - |
KFZ60_RS19360 (4009818) | 4009818..4010348 | - | 531 | WP_000600718.1 | glutathione-regulated potassium-efflux system oxidoreductase KefF | - |
KFZ60_RS19365 (4010459) | 4010459..4011790 | - | 1332 | WP_001183198.1 | MFS transporter | - |
KFZ60_RS19370 (4011849) | 4011849..4012136 | - | 288 | WP_000203741.1 | ferredoxin-like protein FixX | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 105 a.a. Molecular weight: 11737.84 Da Isoelectric Point: 9.8517
>T247308 WP_001160974.1 NZ_CP098231:c4006970-4006656 [Escherichia coli]
MQFTVYRSRSRNAAFPFVIDVTSDIIGVINRRIVIPLTPIERFIRIRPPERLNPILLLVDGKEYVLMTHETATVPVNALG
TKFCDASAHRTLIKGALDFMLDGI
MQFTVYRSRSRNAAFPFVIDVTSDIIGVINRRIVIPLTPIERFIRIRPPERLNPILLLVDGKEYVLMTHETATVPVNALG
TKFCDASAHRTLIKGALDFMLDGI
Download Length: 315 bp
Antitoxin
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A7U9LRR3 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A7U9LTM9 |