Detailed information of TA system TA247308

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): ccdAB/CcdA(antitoxin)
• Location: 4006656..4007206
• Replicon: chromosome
• Accession: NZ_CP098231
• Organism: Escherichia coli strain XJ34

Toxin (Protein)

• Gene name: ccdB
• Uniprot ID: Q32K46
• Locus tag: KFZ60_RS19340
• Protein ID: WP_001160974.1
• Coordinates: 4006656..4006970 (-)
• Length: 105 a.a.

Antitoxin (Protein)

• Gene name: ccdA
• Uniprot ID: V0VEX8
• Locus tag: KFZ60_RS19345
• Protein ID: WP_000125566.1
• Coordinates: 4006973..4007206 (-)
• Length: 78 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin CcdB (2-103)

Antitoxin

• Post-segregation antitoxin CcdA (8-77)

Sequences

Toxin

Protein

• Length: 105 a.a.
• Molecular weight: 11737.84 Da
• Isoelectric Point: 9.8517

>T247308 WP_001160974.1 NZ_CP098231:c4006970-4006656 [Escherichia coli]
MQFTVYRSRSRNAAFPFVIDVTSDIIGVINRRIVIPLTPIERFIRIRPPERLNPILLLVDGKEYVLMTHETATVPVNALG
TKFCDASAHRTLIKGALDFMLDGI

Nucleotide

• Length: 315 bp

Antitoxin

Protein

• Length: 78 a.a.
• Molecular weight: 8530.53 Da
• Isoelectric Point: 5.8062

>AT247308 WP_000125566.1 NZ_CP098231:c4007206-4006973 [Escherichia coli]
MTAKRTTQSVTVTVDRELVNRARDAGLNMSATLTVALNAELKKHAATRWREENAEAIAALNQLADETGCFSDEYRSF

Nucleotide

• Length: 234 bp

Structures

Toxin

• AlphaFold DB: A0A7U9LRR3

Antitoxin

• AlphaFold DB: A0A7U9LTM9