Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3547735..3548353 Replicon chromosome
Accession NZ_CP098231
Organism Escherichia coli strain XJ34

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag KFZ60_RS17150 Protein ID WP_001291435.1
Coordinates 3548135..3548353 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag KFZ60_RS17145 Protein ID WP_000344800.1
Coordinates 3547735..3548109 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KFZ60_RS17135 (3542824) 3542824..3544017 + 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
KFZ60_RS17140 (3544040) 3544040..3547189 + 3150 WP_001132469.1 efflux RND transporter permease AcrB -
KFZ60_RS17145 (3547735) 3547735..3548109 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
KFZ60_RS17150 (3548135) 3548135..3548353 + 219 WP_001291435.1 HHA domain-containing protein Toxin
KFZ60_RS17155 (3548525) 3548525..3549076 + 552 WP_000102564.1 maltose O-acetyltransferase -
KFZ60_RS17160 (3549192) 3549192..3549662 + 471 WP_000136192.1 YlaC family protein -
KFZ60_RS17165 (3549826) 3549826..3551376 + 1551 WP_021577088.1 cyclic-guanylate-specific phosphodiesterase PdeB -
KFZ60_RS17170 (3551418) 3551418..3551771 - 354 WP_000878140.1 DUF1428 domain-containing protein -
KFZ60_RS17175 (3552115) 3552115..3552342 - 228 WP_024183738.1 DUF2188 domain-containing protein -
KFZ60_RS17180 (3552560) 3552560..3553180 - 621 WP_001267012.1 recombinase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T247304 WP_001291435.1 NZ_CP098231:3548135-3548353 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT247304 WP_000344800.1 NZ_CP098231:3547735-3548109 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References