Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-HTH_XRE
Location 3135799..3136504 Replicon chromosome
Accession NZ_CP098231
Organism Escherichia coli strain XJ34

Toxin (Protein)


Gene name relE Uniprot ID A0A246P0D5
Locus tag KFZ60_RS15230 Protein ID WP_000539522.1
Coordinates 3135799..3136185 (+) Length 129 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag KFZ60_RS15235 Protein ID WP_001280945.1
Coordinates 3136175..3136504 (+) Length 110 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KFZ60_RS15210 (3131803) 3131803..3132429 + 627 WP_032280600.1 glutathione S-transferase GstB -
KFZ60_RS15215 (3132426) 3132426..3133541 - 1116 WP_032280599.1 aldose sugar dehydrogenase YliI -
KFZ60_RS15220 (3133652) 3133652..3134035 - 384 WP_000497137.1 biofilm formation regulator BssR -
KFZ60_RS15225 (3134248) 3134248..3135573 + 1326 WP_000049367.1 30S ribosomal protein S12 methylthiotransferase RimO -
KFZ60_RS15230 (3135799) 3135799..3136185 + 387 WP_000539522.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KFZ60_RS15235 (3136175) 3136175..3136504 + 330 WP_001280945.1 DNA-binding transcriptional regulator Antitoxin
KFZ60_RS15240 (3136574) 3136574..3137902 - 1329 WP_000086905.1 GGDEF domain-containing protein -
KFZ60_RS15245 (3137910) 3137910..3140258 - 2349 WP_028132100.1 EAL domain-containing protein -
KFZ60_RS15250 (3140436) 3140436..3141347 - 912 WP_001236044.1 glutathione ABC transporter permease GsiD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(1-124)

Antitoxin

Cro/C1-type helix-turn-helix domain

(53-94)


Sequences

Toxin        


Download         Length: 129 a.a.        Molecular weight: 14292.51 Da        Isoelectric Point: 10.2120

>T247303 WP_000539522.1 NZ_CP098231:3135799-3136185 [Escherichia coli]
MGVYKARRFSQSTKKLGIHDKVLMAAAEEVMQGIWEADLGSGVIKKRLPLQQGKSGGARTIIFFKSANHVFFYDGWSKSG
LSSKGTKEIEDDELAAYKKMANAFLAFSNKQIKDLIETGFLIEVKNER

Download         Length: 387 bp

Antitoxin


Download         Length: 110 a.a.        Molecular weight: 11982.08 Da        Isoelectric Point: 10.0101

>AT247303 WP_001280945.1 NZ_CP098231:3136175-3136504 [Escherichia coli]
MSDKLQMMLEDAKELNALGLMSDSEVDAIAVMVKAREVSARIAKVKSMTGEEIKAIRTRYGMSQSVLAHTMGMSKESVSK
WERNEIKPSGPALRILNTLAIKGPEVFAK

Download         Length: 330 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A246P0D5

Antitoxin

Source ID Structure

References