Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2449182..2449820 Replicon chromosome
Accession NZ_CP098231
Organism Escherichia coli strain XJ34

Toxin (Protein)


Gene name hicA Uniprot ID S1F9G9
Locus tag KFZ60_RS11845 Protein ID WP_000813794.1
Coordinates 2449644..2449820 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag KFZ60_RS11840 Protein ID WP_001270286.1
Coordinates 2449182..2449598 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KFZ60_RS11820 (2444334) 2444334..2445275 - 942 WP_001251315.1 ABC transporter permease -
KFZ60_RS11825 (2445276) 2445276..2446289 - 1014 WP_086217925.1 ABC transporter ATP-binding protein -
KFZ60_RS11830 (2446307) 2446307..2447452 - 1146 WP_088376267.1 ABC transporter substrate-binding protein -
KFZ60_RS11835 (2447697) 2447697..2449103 - 1407 WP_000760626.1 PLP-dependent aminotransferase family protein -
KFZ60_RS11840 (2449182) 2449182..2449598 - 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
KFZ60_RS11845 (2449644) 2449644..2449820 - 177 WP_000813794.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
KFZ60_RS11850 (2450042) 2450042..2450272 + 231 WP_000494244.1 YncJ family protein -
KFZ60_RS11855 (2450364) 2450364..2452325 - 1962 WP_021577429.1 23S rRNA 5-hydroxycytidine C2501 synthase -
KFZ60_RS11860 (2452398) 2452398..2452934 - 537 WP_021577428.1 DNA-binding transcriptional regulator SutR -
KFZ60_RS11865 (2452987) 2452987..2454201 + 1215 WP_089534812.1 BenE family transporter YdcO -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 2454241..2455389 1148


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6749.83 Da        Isoelectric Point: 11.2298

>T247302 WP_000813794.1 NZ_CP098231:c2449820-2449644 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT247302 WP_001270286.1 NZ_CP098231:c2449598-2449182 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6HPB

Antitoxin

Source ID Structure

References