Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 293026..293657 Replicon chromosome
Accession NZ_CP098231
Organism Escherichia coli strain XJ34

Toxin (Protein)


Gene name hicA Uniprot ID A0A1M1UJK7
Locus tag KFZ60_RS01295 Protein ID WP_001259382.1
Coordinates 293026..293301 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID U9Y7E1
Locus tag KFZ60_RS01300 Protein ID WP_000593555.1
Coordinates 293298..293657 (+) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KFZ60_RS01280 (288030) 288030..289097 + 1068 WP_000361491.1 HlyD family efflux transporter periplasmic adaptor subunit -
KFZ60_RS01285 (289094) 289094..291829 + 2736 WP_115978146.1 ribosome-associated ATPase/putative transporter RbbA -
KFZ60_RS01290 (291829) 291829..292953 + 1125 WP_001314210.1 ABC transporter permease -
KFZ60_RS01295 (293026) 293026..293301 + 276 WP_001259382.1 type II toxin-antitoxin system HicA family toxin Toxin
KFZ60_RS01300 (293298) 293298..293657 + 360 WP_000593555.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
KFZ60_RS01305 (293777) 293777..294178 - 402 WP_001190062.1 nickel-responsive transcriptional regulator NikR -
KFZ60_RS01310 (294184) 294184..294990 - 807 WP_088375933.1 nickel import ATP-binding protein NikE -
KFZ60_RS01315 (294987) 294987..295751 - 765 WP_062893069.1 nickel import ATP-binding protein NikD -
KFZ60_RS01320 (295751) 295751..296584 - 834 WP_001008963.1 nickel ABC transporter permease subunit NikC -
KFZ60_RS01325 (296581) 296581..297525 - 945 WP_032281756.1 nickel ABC transporter permease subunit NikB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 284191..293657 9466


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(30-80)

Antitoxin

Uncharacterised protein family HicB

(60-112)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10185.91 Da        Isoelectric Point: 10.7076

>T247291 WP_001259382.1 NZ_CP098231:293026-293301 [Escherichia coli]
MRTKVQALRKKQKNTLDQIFKSPVPQGIKWSDIESLVKALGGEIKEGRGSRCKFILNMSVACFHRPHPSPDTDKGAVESV
RDWLLSIGVKP

Download         Length: 276 bp

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13402.27 Da        Isoelectric Point: 5.1987

>AT247291 WP_000593555.1 NZ_CP098231:293298-293657 [Escherichia coli]
MIKLKTPNSMEIAGQPAVITYVPELNAFRGKFLGLSGYCDFVSDSIQGLQKEGELSLREYLEDCKAAGIEPYARTEKIKT
FTLRYPESLSERLNNAAAQQQVSVNTYIIETLNERLNHL

Download         Length: 360 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1M1UJK7

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LKZ6

References