Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | hipBA/HipA-HipB |
Location | 162968..164591 | Replicon | plasmid unnamed1 |
Accession | NZ_CP098230 | ||
Organism | Escherichia coli strain XJ55 |
Toxin (Protein)
Gene name | hipA | Uniprot ID | H9TH67 |
Locus tag | KFZ57_RS24515 | Protein ID | WP_000088046.1 |
Coordinates | 162968..164293 (-) | Length | 442 a.a. |
Antitoxin (Protein)
Gene name | hipB | Uniprot ID | A0A5Z6V2D1 |
Locus tag | KFZ57_RS24520 | Protein ID | WP_024136327.1 |
Coordinates | 164298..164591 (-) | Length | 98 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
KFZ57_RS24485 (KFZ57_24415) | 159233..159613 | + | 381 | WP_001426317.1 | hypothetical protein | - |
KFZ57_RS24490 (KFZ57_24420) | 159671..160336 | + | 666 | WP_000490638.1 | hypothetical protein | - |
KFZ57_RS24500 (KFZ57_24430) | 161361..162176 | - | 816 | WP_053276223.1 | HNH endonuclease signature motif containing protein | - |
KFZ57_RS24505 (KFZ57_24435) | 162189..162599 | - | 411 | WP_000985911.1 | hypothetical protein | - |
KFZ57_RS24510 (KFZ57_24440) | 162701..162907 | - | 207 | WP_000134171.1 | hypothetical protein | - |
KFZ57_RS24515 (KFZ57_24445) | 162968..164293 | - | 1326 | WP_000088046.1 | type II toxin-antitoxin system HipA family toxin | Toxin |
KFZ57_RS24520 (KFZ57_24450) | 164298..164591 | - | 294 | WP_024136327.1 | helix-turn-helix transcriptional regulator | Antitoxin |
KFZ57_RS24525 (KFZ57_24455) | 165195..165587 | - | 393 | WP_000341066.1 | hypothetical protein | - |
KFZ57_RS24530 (KFZ57_24460) | 165960..166301 | + | 342 | WP_001151575.1 | hypothetical protein | - |
KFZ57_RS24535 (KFZ57_24465) | 166393..166584 | + | 192 | WP_000398480.1 | hypothetical protein | - |
KFZ57_RS24540 (KFZ57_24470) | 166634..166915 | + | 282 | WP_000077926.1 | hypothetical protein | - |
KFZ57_RS24545 | 167256..167387 | - | 132 | WP_000374059.1 | hypothetical protein | - |
KFZ57_RS24550 (KFZ57_24475) | 167478..168719 | - | 1242 | WP_001053338.1 | VWA domain-containing protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Conjugative plasmid | blaCTX-M-55 / mph(A) / aac(3)-IId / sul1 / qacE / qnrB6 / dfrA27 / ARR-3 / aac(6')-Ib-cr / floR / tet(A) / aph(6)-Id / aph(3'')-Ib / sul2 / blaTEM-1B | - | 1..230802 | 230802 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 442 a.a. Molecular weight: 50249.20 Da Isoelectric Point: 6.1927
>T247290 WP_000088046.1 NZ_CP098230:c164293-162968 [Escherichia coli]
MSRKQQRLVIWMNGIKVGYWEKSKGVDSLEYLPEWVADEQGRPLSLSLPFTPGNQVWRGNVVRDYFDNLLPDSEGIRRRL
AMRYKADSLEPFDLLTELGKDCVGAIQLLHDGDEPTDLYSVKYHPLTESEIAATLRNTTETLLPGRPEDNDDLRLSIAGA
QEKTALLWHEDRWCMPEGNTPTTHIFKLPLGLVGNMKADMSSSVENEWLCSVLLGQYGLPVARTQIAHFEDQKALVVERF
DRKWSGDGQWIIRLPQEDMCQALGVSPLRKYQADGGPGISEIMEVLSNSDRAERDKAQFFMTQIIFWMMAATDGHAKNFS
ISIGPQGRYHLTPNYDVLSAWPVIGHGNNQISWQKCKLAMAVRGSSNYYQIYRIQRRHWIRHGEITGLSKQQTEAMIEEI
IARTPGVIERVSGLLPDQFPQQLAESIFDGMRQQCRRLAEK
MSRKQQRLVIWMNGIKVGYWEKSKGVDSLEYLPEWVADEQGRPLSLSLPFTPGNQVWRGNVVRDYFDNLLPDSEGIRRRL
AMRYKADSLEPFDLLTELGKDCVGAIQLLHDGDEPTDLYSVKYHPLTESEIAATLRNTTETLLPGRPEDNDDLRLSIAGA
QEKTALLWHEDRWCMPEGNTPTTHIFKLPLGLVGNMKADMSSSVENEWLCSVLLGQYGLPVARTQIAHFEDQKALVVERF
DRKWSGDGQWIIRLPQEDMCQALGVSPLRKYQADGGPGISEIMEVLSNSDRAERDKAQFFMTQIIFWMMAATDGHAKNFS
ISIGPQGRYHLTPNYDVLSAWPVIGHGNNQISWQKCKLAMAVRGSSNYYQIYRIQRRHWIRHGEITGLSKQQTEAMIEEI
IARTPGVIERVSGLLPDQFPQQLAESIFDGMRQQCRRLAEK
Download Length: 1326 bp
Antitoxin
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A3T0VBU1 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A5Z6V2D1 |