Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type V Classification (family/domain) ghoTS/ghoT-GhoS
Location 4367475..4367972 Replicon chromosome
Accession NZ_CP098229
Organism Escherichia coli strain XJ55

Toxin (Protein)


Gene name ghoT Uniprot ID L4JJG6
Locus tag KFZ57_RS21400 Protein ID WP_001173343.1
Coordinates 4367475..4367648 (-) Length 58 a.a.

Antitoxin (Protein)


Gene name ghoS Uniprot ID L4JK92
Locus tag KFZ57_RS21405 Protein ID WP_000398619.1
Coordinates 4367676..4367972 (-) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KFZ57_RS21390 (4364145) 4364145..4365602 + 1458 WP_000856829.1 dipeptide/tripeptide permease DtpC -
KFZ57_RS21395 (4365839) 4365839..4367356 + 1518 WP_001295074.1 lysine--tRNA ligase -
KFZ57_RS21400 (4367475) 4367475..4367648 - 174 WP_001173343.1 type V toxin-antitoxin system toxin GhoT Toxin
KFZ57_RS21405 (4367676) 4367676..4367972 - 297 WP_000398619.1 type V toxin-antitoxin system endoribonuclease antitoxin GhoS Antitoxin
KFZ57_RS21410 (4368199) 4368199..4368471 - 273 WP_000405647.1 GNAT family N-acetyltransferase -
KFZ57_RS21415 (4368483) 4368483..4368713 - 231 WP_000371698.1 4Fe-4S mono-cluster protein YjdI -
KFZ57_RS21420 (4368894) 4368894..4370525 + 1632 WP_001216461.1 sensor histidine kinase -
KFZ57_RS21425 (4370522) 4370522..4371241 + 720 WP_000611288.1 two-component system response regulator DcuR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin GhoT/OrtT

(4-57)

Antitoxin

Endoribonuclease antitoxin GhoS

(5-94)


Sequences

Toxin        


Download         Length: 58 a.a.        Molecular weight: 6555.06 Da        Isoelectric Point: 10.2288

>T247288 WP_001173343.1 NZ_CP098229:c4367648-4367475 [Escherichia coli]
MALFSKILIFYVIGVNISFVIIWFISHEKTHIRLLSAFLVGITWPMSLPVALLFSLF

Download         Length: 174 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11467.97 Da        Isoelectric Point: 4.1705

>AT247288 WP_000398619.1 NZ_CP098229:c4367972-4367676 [Escherichia coli]
MEGKNKFNTYVVSFDYPSSYSSVFLRLRSLMYDMNFSSIVADEYGIPRQLNENSFAITTSLAASEIEDLIRLKCLDLPDI
DFDLNIMTVDDYFRQFYK

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9QI41

Antitoxin

Source ID Structure
PDB 2LLZ
AlphaFold DB A0A7U9QBH6

References