Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 4264964..4265559 Replicon chromosome
Accession NZ_CP098229
Organism Escherichia coli strain XJ55

Toxin (Protein)


Gene name chpB Uniprot ID U9Y4M4
Locus tag KFZ57_RS20885 Protein ID WP_000239579.1
Coordinates 4264964..4265314 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID U9Y2K1
Locus tag KFZ57_RS20890 Protein ID WP_001223208.1
Coordinates 4265308..4265559 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KFZ57_RS20865 (4260240) 4260240..4261262 - 1023 WP_001317446.1 ABC transporter permease -
KFZ57_RS20870 (4261276) 4261276..4262778 - 1503 WP_000205793.1 sugar ABC transporter ATP-binding protein -
KFZ57_RS20875 (4263088) 4263088..4264044 - 957 WP_000265933.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
KFZ57_RS20880 (4264354) 4264354..4264884 + 531 WP_000055072.1 inorganic diphosphatase -
KFZ57_RS20885 (4264964) 4264964..4265314 - 351 WP_000239579.1 endoribonuclease toxin ChpB Toxin
KFZ57_RS20890 (4265308) 4265308..4265559 - 252 WP_001223208.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
KFZ57_RS20895 (4265772) 4265772..4266113 - 342 WP_001219160.1 gamma-glutamylcyclotransferase -
KFZ57_RS20900 (4266116) 4266116..4269895 - 3780 WP_000060901.1 autotransporter assembly complex protein TamB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12511.45 Da        Isoelectric Point: 5.6219

>T247287 WP_000239579.1 NZ_CP098229:c4265314-4264964 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLRARLAKRIGLAADEVVEEALLRLQAVVE

Download         Length: 351 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9271.58 Da        Isoelectric Point: 4.4201

>AT247287 WP_001223208.1 NZ_CP098229:c4265559-4265308 [Escherichia coli]
MRITIKRWGNSAGMVIPNIVMKELNLQPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNAAELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y8A8

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LQ26

References