247286

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) sanaTA/AbiEii-DUF6088
Location 4213613..4214948 Replicon chromosome
Accession NZ_CP098229
Organism Escherichia coli strain XJ55

Toxin (Protein)


Gene name sanaT Uniprot ID F4VMR9
Locus tag KFZ57_RS20645 Protein ID WP_000342497.1
Coordinates 4213613..4214560 (-) Length 316 a.a.

Antitoxin (Protein)


Gene name sanaA Uniprot ID A0A228Z6F8
Locus tag KFZ57_RS20650 Protein ID WP_000152739.1
Coordinates 4214553..4214948 (-) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KFZ57_RS20615 (4209466) 4209466..4210182 + 717 WP_001295734.1 N-acetylneuraminic acid outer membrane channel NanC -
KFZ57_RS20620 (4210202) 4210202..4211308 + 1107 WP_001298927.1 N-acetylneuraminate epimerase -
KFZ57_RS20625 (4211373) 4211373..4212353 + 981 WP_000991446.1 sialate O-acetylesterase -
KFZ57_RS20630 (4212361) 4212361..4213011 - 651 WP_001037963.1 HNH endonuclease -
KFZ57_RS20635 (4213148) 4213148..4213291 + 144 Protein_4040 HNH endonuclease -
KFZ57_RS20640 (4213390) 4213390..4213575 + 186 WP_000066585.1 hypothetical protein -
KFZ57_RS20645 (4213613) 4213613..4214560 - 948 WP_000342497.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
KFZ57_RS20650 (4214553) 4214553..4214948 - 396 WP_000152739.1 DUF6088 family protein Antitoxin
KFZ57_RS20655 (4215018) 4215018..4215851 - 834 WP_001192741.1 DUF4942 domain-containing protein -
KFZ57_RS20660 (4216157) 4216157..4217713 + 1557 WP_000202816.1 type I restriction-modification system subunit M -
KFZ57_RS20665 (4217710) 4217710..4218876 + 1167 WP_001293040.1 restriction endonuclease subunit S -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - fimE / fimB 4206334..4218876 12542


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(38-303)

Antitoxin

Protein of unknown function DUF6088

(7-108)


Sequences

Toxin        


Download         Length: 316 a.a.        Molecular weight: 35588.79 Da        Isoelectric Point: 4.9737

>T247286 WP_000342497.1 NZ_CP098229:c4214560-4213613 [Escherichia coli]
MDDLTTLFSEVADALGIESVAIVEKDHYIVELLQLLKPLVFDTHQLVFAGGTALAKSGVALNRMSEDVDIKLVPKDAFQA
LSRTQRKNTRKEIVQAVSSAIASSGVFNFDDDYPKVTRDEYRYNDIPVRYPQRVVQAPCLRPFIRLELMEAKLLEPSELR
DIHSLVTGITGKAAIVSAFPCATIISTQAEKLVAMLRRTAAVVRDVERFDDASLVRHIYDTNCIVETSHVDMSLLVDFVQ
QTIEQDIQRYGNQYPQFCASPVDELKMGLDELANNPLYQMRYQQFVSPMVYGERKITWDEAYSRFRSLALAILNA

Download         Length: 948 bp

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14605.90 Da        Isoelectric Point: 11.6915

>AT247286 WP_000152739.1 NZ_CP098229:c4214948-4214553 [Escherichia coli]
MTIKARIQSRLKRSKRYVFTRDDFKDIAGYDQVGRVLRDLVREGQLLKVGYGVYTKARRNGITGKVMPAAPGGSSAVIVE
TLERLKVRYRFAGATQAYNSGTSTQIPASPEIKTPRRFKRVLSVGNSRLNG

Download         Length: 396 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1L5BAQ6

Antitoxin

Source ID Structure
AlphaFold DB A0A228Z6F8

References