247284

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) itaRT/DUF1778(antitoxin)
Location 3610407..3611244 Replicon chromosome
Accession NZ_CP098229
Organism Escherichia coli strain XJ55

Toxin (Protein)


Gene name itaT Uniprot ID Q3Z4X7
Locus tag KFZ57_RS17715 Protein ID WP_000227784.1
Coordinates 3610702..3611244 (+) Length 181 a.a.

Antitoxin (Protein)


Gene name itaR Uniprot ID I2UQS9
Locus tag KFZ57_RS17710 Protein ID WP_001297137.1
Coordinates 3610407..3610718 (+) Length 104 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KFZ57_RS17685 (3605427) 3605427..3606374 + 948 WP_001239441.1 cytochrome o ubiquinol oxidase subunit II -
KFZ57_RS17690 (3606396) 3606396..3608387 + 1992 WP_000467180.1 cytochrome o ubiquinol oxidase subunit I -
KFZ57_RS17695 (3608377) 3608377..3608991 + 615 WP_000179819.1 cytochrome o ubiquinol oxidase subunit III -
KFZ57_RS17700 (3608991) 3608991..3609320 + 330 WP_000019869.1 cytochrome o ubiquinol oxidase subunit IV -
KFZ57_RS17705 (3609332) 3609332..3610222 + 891 WP_000971336.1 heme o synthase -
KFZ57_RS17710 (3610407) 3610407..3610718 + 312 WP_001297137.1 DUF1778 domain-containing protein Antitoxin
KFZ57_RS17715 (3610702) 3610702..3611244 + 543 WP_000227784.1 GNAT family N-acetyltransferase Toxin
KFZ57_RS17720 (3611300) 3611300..3612235 - 936 WP_001297127.1 tetratricopeptide repeat protein -
KFZ57_RS17725 (3612643) 3612643..3614007 + 1365 WP_001000978.1 MFS transporter -
KFZ57_RS17730 (3614135) 3614135..3614626 - 492 WP_001138904.1 nucleotide binding protein YajQ -
KFZ57_RS17735 (3614794) 3614794..3615705 + 912 WP_000705847.1 2-dehydropantoate 2-reductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(68-156)

Antitoxin

Vibrio phage ICP1, Orf50

(14-97)


Sequences

Toxin        


Download         Length: 181 a.a.        Molecular weight: 19805.02 Da        Isoelectric Point: 8.3395

>T247284 WP_000227784.1 NZ_CP098229:3610702-3611244 [Escherichia coli]
MVDKHEEITLPIVLSCNYQSDITYPGQKQFDCGNPVIDKFVRASLKKSVRNSDCAAKALIDRQSGELIGICTFTAYSLEK
QRVSGVLQGSQPSEIGVVRLVMLGVARKYQKRGFGQDLLCDFFEHVKIIHQALPIKGVYLDADPAAINFYARLGFVQLSA
TPNAFGAVPMFLAIQHILAA

Download         Length: 543 bp

Antitoxin


Download         Length: 104 a.a.        Molecular weight: 11358.04 Da        Isoelectric Point: 10.4825

>AT247284 WP_001297137.1 NZ_CP098229:3610407-3610718 [Escherichia coli]
MPGKTATLPDVDKTLKNARVELKTSPDAKNKLREAAQAVGVDLSAFILSAAMERAESVLDNQRRRELSNQSWELMNQLIA
EPAQPTLALKALMKRKNSDGRQA

Download         Length: 312 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7BYY

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0Y6B3

References