247283

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3576330..3576948 Replicon chromosome
Accession NZ_CP098229
Organism Escherichia coli strain XJ55

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag KFZ57_RS17545 Protein ID WP_001291435.1
Coordinates 3576730..3576948 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag KFZ57_RS17540 Protein ID WP_000344800.1
Coordinates 3576330..3576704 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KFZ57_RS17530 (3571419) 3571419..3572612 + 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
KFZ57_RS17535 (3572635) 3572635..3575784 + 3150 WP_001132469.1 efflux RND transporter permease AcrB -
KFZ57_RS17540 (3576330) 3576330..3576704 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
KFZ57_RS17545 (3576730) 3576730..3576948 + 219 WP_001291435.1 HHA domain-containing protein Toxin
KFZ57_RS17550 (3577120) 3577120..3577671 + 552 WP_000102568.1 maltose O-acetyltransferase -
KFZ57_RS17555 (3577787) 3577787..3578257 + 471 WP_000136192.1 YlaC family protein -
KFZ57_RS17560 (3578421) 3578421..3579971 + 1551 WP_001299455.1 cyclic-guanylate-specific phosphodiesterase PdeB -
KFZ57_RS17565 (3580013) 3580013..3580366 - 354 WP_000878140.1 DUF1428 domain-containing protein -
KFZ57_RS17575 (3580745) 3580745..3581056 + 312 WP_000409911.1 MGMT family protein -
KFZ57_RS17580 (3581087) 3581087..3581659 - 573 WP_000779831.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T247283 WP_001291435.1 NZ_CP098229:3576730-3576948 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT247283 WP_000344800.1 NZ_CP098229:3576330-3576704 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References