Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/ElaA-DUF1778
Location 72763..73502 Replicon plasmid pECL_A
Accession NC_014107
Organism Enterobacter cloacae subsp. cloacae ATCC 13047

Toxin (Protein)


Gene name tacT Uniprot ID A0A5E1AVR5
Locus tag ECL_RS26225 Protein ID WP_013087172.1
Coordinates 73017..73502 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID A0A5E1AWX8
Locus tag ECL_RS26220 Protein ID WP_012540086.1
Coordinates 72763..73029 (+) Length 89 a.a.

Genomic Context

ECL_RS26220ECL_RS26225ECL_RS26230ECL_RS26190ECL_RS26195ECL_RS26200ECL_RS26205ECL_RS26210ECL_RS26215ECL_RS26235ECL_RS26240ECL_RS26245
Location: 72763..73029 (267 bp)
Type: Antitoxin
Protein ID: WP_012540086.1
Location: 73017..73502 (486 bp)
Type: Toxin
Protein ID: WP_013087172.1
Location: 73921..75261 (1341 bp)
Type: Others
Protein ID: WP_000589001.1
Location: 67993..68529 (537 bp)
Type: Others
Protein ID: WP_013087166.1
Location: 68654..70405 (1752 bp)
Type: Others
Protein ID: WP_162875198.1
Location: 70432..70794 (363 bp)
Type: Others
Protein ID: WP_013087168.1
Location: 70870..71415 (546 bp)
Type: Others
Protein ID: WP_013087169.1
Location: 71424..72137 (714 bp)
Type: Others
Protein ID: WP_013087170.1
Location: 72139..72462 (324 bp)
Type: Others
Protein ID: WP_013087171.1
Location: 75517..75939 (423 bp)
Type: Others
Protein ID: WP_032072095.1
Location: 76101..77231 (1131 bp)
Type: Others
Protein ID: WP_004196366.1
Location: 77244..77513 (270 bp)
Type: Others
Protein ID: WP_004196355.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
ECL_RS2619067993..68529-537WP_013087166.1GNAT family N-acetyltransferase-
ECL_RS2619568654..70405-1752WP_162875198.1arsenical pump-driving ATPase-
ECL_RS2620070432..70794-363WP_013087168.1arsenic metallochaperone ArsD family protein-
ECL_RS2620570870..71415-546WP_013087169.1sigma-70 family RNA polymerase sigma factor-
ECL_RS2621071424..72137-714WP_013087170.1arsenical resistance protein ArsH-
ECL_RS2621572139..72462-324WP_013087171.1metalloregulator ArsR/SmtB family transcription factor-
ECL_RS2622072763..73029+267WP_012540086.1DUF1778 domain-containing proteinAntitoxin
ECL_RS2622573017..73502+486WP_013087172.1GNAT family N-acetyltransferaseToxin
ECL_RS2623073921..75261+1341WP_000589001.1ISNCY family transposase-
ECL_RS2623575517..75939-423WP_032072095.1nickel resistance OB fold protein NcrY-
ECL_RS2624076101..77231-1131WP_004196366.1Ni(II)/Co(II) efflux transporter permease subunit NcrC-
ECL_RS2624577244..77513-270WP_004196355.1nickel-sensing transcriptional repressor NcrB-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideNon-Mobilizable plasmid--1..199562199562


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(27-152)

Antitoxin

Vibrio phage ICP1, Orf50

(2-87)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17810.62 Da        Isoelectric Point: 9.8560

>T24728 WP_013087172.1 NC_014107:73017-73502 [Enterobacter cloacae subsp. cloacae ATCC 13047]
VGRVTVPEPLSSFHQVAEFVCGETVLDDWLKQKGLKNQALGSARTFVVCKKDTKQVAGFYSLATGSVNHTEATGNLRRNM
PDPIPVIILARLAVDLSFRGKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKNFYIHHGFKPSQTQQRTLFLKLP
Q

Download         Length: 486 bp

>T24728 NC_014107:73017-73502 [Enterobacter cloacae subsp. cloacae ATCC 13047]
GTGGGACGTGTAACAGTACCAGAACCTTTATCCAGCTTTCATCAGGTGGCGGAATTCGTTTGCGGTGAAACTGTTCTGGA
TGACTGGTTAAAGCAGAAAGGCCTCAAAAACCAGGCTCTCGGATCGGCCAGAACGTTTGTAGTGTGTAAAAAAGACACGA
AACAAGTAGCCGGTTTTTACTCTCTGGCCACCGGGAGCGTCAACCATACAGAAGCGACAGGCAATCTTCGGCGTAACATG
CCCGATCCCATCCCTGTTATTATACTTGCCCGTCTTGCTGTCGATCTCTCTTTCCGCGGAAAAGGGCTTGGCGCTGATTT
ACTTCATGATGCAGTGCTTCGTTGCTATCGGGTTGCCGAGAATATTGGTGTACGTGCAATCATGGTTCATGCACTCACCG
AAGAAGCTAAAAATTTCTACATTCACCATGGTTTCAAACCATCACAAACTCAGCAACGGACATTATTTCTTAAACTCCCT
CAATAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10076.47 Da        Isoelectric Point: 4.3721

>AT24728 WP_012540086.1 NC_014107:72763-73029 [Enterobacter cloacae subsp. cloacae ATCC 13047]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACQAAENVILDRRVFNFNDEQYAEFIDMLDAPVADDPAIDKLL
ARKPQWDV

Download         Length: 267 bp

>AT24728 NC_014107:72763-73029 [Enterobacter cloacae subsp. cloacae ATCC 13047]
ATGAAATCAGATGTTCAACTTAATCTTAGAGCAAAGGAATCACAGCGGGCGCTCATTGATGCTGCTGCGGAAATTCTTCA
CAAATCACGAACAGACTTCATCCTGGAAATGGCCTGTCAGGCCGCTGAGAACGTGATCCTCGATCGCCGGGTCTTTAATT
TTAACGATGAACAATATGCCGAATTCATCGACATGCTTGATGCCCCTGTTGCAGATGATCCTGCCATAGATAAACTGCTG
GCAAGGAAACCTCAGTGGGACGTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A5E1AVR5

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A5E1AWX8

References