247279

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 2343000..2343526 Replicon chromosome
Accession NZ_CP098229
Organism Escherichia coli strain XJ55

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag KFZ57_RS11465 Protein ID WP_000323025.1
Coordinates 2343239..2343526 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S1F6D3
Locus tag KFZ57_RS11460 Protein ID WP_000534858.1
Coordinates 2343000..2343239 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KFZ57_RS11430 (2338362) 2338362..2338851 + 490 Protein_2233 class I SAM-dependent methyltransferase -
KFZ57_RS11435 (2339329) 2339329..2339750 + 422 Protein_2234 hypothetical protein -
KFZ57_RS11440 (2340406) 2340406..2341428 + 1023 Protein_2235 ISNCY family transposase -
KFZ57_RS11445 (2341549) 2341549..2341698 + 150 WP_011443592.1 protein YdfW -
KFZ57_RS11450 (2342135) 2342135..2342467 - 333 WP_001301033.1 FlxA-like family protein -
KFZ57_RS11455 (2342670) 2342670..2342975 - 306 WP_001326990.1 protein YdfV -
KFZ57_RS11460 (2343000) 2343000..2343239 + 240 WP_000534858.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
KFZ57_RS11465 (2343239) 2343239..2343526 + 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
KFZ57_RS11470 (2343598) 2343598..2343753 + 156 WP_000813254.1 type I toxin-antitoxin system toxin HokD -
KFZ57_RS11475 (2343970) 2343970..2344221 + 252 WP_000980994.1 protein Rem -
KFZ57_RS11480 (2344288) 2344288..2344566 + 279 WP_012304870.1 hypothetical protein -
KFZ57_RS11485 (2344568) 2344568..2345617 + 1050 WP_275801813.1 DUF968 domain-containing protein -
KFZ57_RS11490 (2345631) 2345631..2346383 + 753 WP_001047135.1 antitermination protein -
KFZ57_RS11495 (2346661) 2346661..2346750 - 90 WP_120795389.1 hypothetical protein -
KFZ57_RS11500 (2346805) 2346805..2347017 - 213 WP_000087756.1 cold shock-like protein CspF -
KFZ57_RS11505 (2347318) 2347318..2347533 + 216 WP_000066484.1 cold shock-like protein CspB -
KFZ57_RS11510 (2347897) 2347897..2348067 - 171 WP_211180497.1 putative zinc-binding protein YnfU -
KFZ57_RS11515 (2348287) 2348287..2348502 + 216 WP_000839590.1 phage lysis protein EssD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2318131..2379190 61059


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-79)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T247279 WP_000323025.1 NZ_CP098229:2343239-2343526 [Escherichia coli]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9071.48 Da        Isoelectric Point: 4.5230

>AT247279 WP_000534858.1 NZ_CP098229:2343000-2343239 [Escherichia coli]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL

Download         Length: 240 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9

Antitoxin

Source ID Structure
AlphaFold DB A0A4V1CTS8

References