Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 1382602..1383227 Replicon chromosome
Accession NZ_CP098229
Organism Escherichia coli strain XJ55

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag KFZ57_RS06715 Protein ID WP_000911330.1
Coordinates 1382829..1383227 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID U9XQV3
Locus tag KFZ57_RS06710 Protein ID WP_000450524.1
Coordinates 1382602..1382829 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KFZ57_RS06685 (1378405) 1378405..1378875 - 471 WP_001068682.1 thioredoxin-dependent thiol peroxidase -
KFZ57_RS06690 (1378875) 1378875..1379447 - 573 WP_000176187.1 glycine cleavage system transcriptional repressor -
KFZ57_RS06695 (1379593) 1379593..1380471 + 879 WP_001295469.1 4-hydroxy-tetrahydrodipicolinate synthase -
KFZ57_RS06700 (1380488) 1380488..1381522 + 1035 WP_001297320.1 outer membrane protein assembly factor BamC -
KFZ57_RS06705 (1381735) 1381735..1382448 + 714 WP_024186347.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -
KFZ57_RS06710 (1382602) 1382602..1382829 + 228 WP_000450524.1 toxin-antitoxin system antitoxin VapB Antitoxin
KFZ57_RS06715 (1382829) 1382829..1383227 + 399 WP_000911330.1 type II toxin-antitoxin system VapC family toxin Toxin
KFZ57_RS06720 (1383374) 1383374..1384237 + 864 WP_001267508.1 neutral zinc metallopeptidase -
KFZ57_RS06725 (1384252) 1384252..1386267 + 2016 WP_000829329.1 tRNA cytosine(34) acetyltransferase TmcA -
KFZ57_RS06730 (1386341) 1386341..1387039 + 699 WP_000679823.1 esterase -
KFZ57_RS06735 (1387149) 1387149..1387349 - 201 WP_000383836.1 YpfN family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14894.25 Da        Isoelectric Point: 9.2216

>T247273 WP_000911330.1 NZ_CP098229:1382829-1383227 [Escherichia coli]
MLKFMLDTNICIFTIKNKPVHVRERFNLNSGRMCISSVTLMELIYGAEKSQMPERNLAVIEGFVSRLVVLDYDSAAATHT
GQIRAELARQGRPVGPFDQMIAGHARSRGLIVVTNNTREFERVAGIRLEDWS

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8498.61 Da        Isoelectric Point: 4.3867

>AT247273 WP_000450524.1 NZ_CP098229:1382602-1382829 [Escherichia coli]
METTVFLSNRSQAVRLPKAVALPEDVKKVEIIAIGRTRIITPAGESWDSWFDGENVSADFMDIRDQPAMQERESF

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A829CM33

References