Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 147898..149521 Replicon plasmid unnamed1
Accession NZ_CP098228
Organism Escherichia coli strain XJ6-3

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag KFZ54_RS24275 Protein ID WP_106474238.1
Coordinates 148196..149521 (+) Length 442 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A5Z6V2D1
Locus tag KFZ54_RS24270 Protein ID WP_024136327.1
Coordinates 147898..148191 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KFZ54_RS24240 (KFZ54_24160) 143770..145011 + 1242 WP_001053338.1 VWA domain-containing protein -
KFZ54_RS24245 145102..145233 + 132 WP_000374059.1 hypothetical protein -
KFZ54_RS24250 (KFZ54_24165) 145574..145855 - 282 WP_000077926.1 hypothetical protein -
KFZ54_RS24255 (KFZ54_24170) 145905..146096 - 192 WP_000398480.1 hypothetical protein -
KFZ54_RS24260 (KFZ54_24175) 146188..146529 - 342 WP_001151575.1 hypothetical protein -
KFZ54_RS24265 (KFZ54_24180) 146902..147294 + 393 WP_000341066.1 hypothetical protein -
KFZ54_RS24270 (KFZ54_24185) 147898..148191 + 294 WP_024136327.1 helix-turn-helix transcriptional regulator Antitoxin
KFZ54_RS24275 (KFZ54_24190) 148196..149521 + 1326 WP_106474238.1 type II toxin-antitoxin system HipA family toxin Toxin
KFZ54_RS24280 (KFZ54_24195) 149582..149788 + 207 WP_000134171.1 hypothetical protein -
KFZ54_RS24285 (KFZ54_24200) 149890..150300 + 411 WP_000985911.1 hypothetical protein -
KFZ54_RS24290 (KFZ54_24205) 150313..151128 + 816 WP_001572439.1 HNH endonuclease signature motif containing protein -
KFZ54_RS24295 (KFZ54_24210) 151382..151807 + 426 WP_001043843.1 hypothetical protein -
KFZ54_RS24300 (KFZ54_24215) 152261..152497 + 237 Protein_152 type I restriction-modification system subunit M N-terminal domain-containing protein -
KFZ54_RS24305 (KFZ54_24220) 152552..152851 + 300 WP_001572440.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid floR / blaCTX-M-65 / dfrA14 / ant(3'')-Ia / blaOXA-10 / cmlA1 / qnrS1 / tet(A) - 1..181896 181896


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(155-404)

Antitoxin

Cro/C1-type helix-turn-helix domain

(21-69)


Sequences

Toxin        


Download         Length: 442 a.a.        Molecular weight: 50248.21 Da        Isoelectric Point: 6.3505

>T247266 WP_106474238.1 NZ_CP098228:148196-149521 [Escherichia coli]
MSRKQQRLVIWMNGIKVGYWEKSKGVDSLEYLPEWVADEQGRPLSLSLPFTPGNQVWRGNVVRDYFDNLLPDSEGIRRRL
AMRYKADSLEPFDLLTELGKDCVGAIQLLHDGDEPTDLYSVKYHPLTESEIAATLRNTTETLLPGRPEDNDDLRLSIAGA
QEKTALLWHQDRWCMPEGNTPTTHIFKLPLGLVGNMKADMSSSVENEWLCSVLLGQYGLPVARTQIAHFEDQKALVVERF
DRKWSGDGQWIIRLPQEDMCQALGVSPLRKYQADGGPGISEIMEVLSNSDRAERDKAQFFMTQIIFWMMAATDGHAKNFS
ISIGPQGRYHLTPNYDVLSAWPVIGHGNNQISWQKCKLAMAVRGSSNYYQIYRIQRRHWIRHGEITGLSKQQTEAMIEEI
IARTPGVIERVSGLLPDQFPQQLAESIFDGMRQQCRRLAEK

Download         Length: 1326 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10946.35 Da        Isoelectric Point: 10.0925

>AT247266 WP_024136327.1 NZ_CP098228:147898-148191 [Escherichia coli]
INNDYPLNTLNQLRPLLIGFRKANGLTQKDLSERLGVTQQTYSRLEANPASASIERLFKVFSILGVKISFSSATTSSERK
QTEEMLKSNSPARQEDW

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A5Z6V2D1

References