247264

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yjhX-yjhQ/YjhX-GNAT
Location 4174891..4175705 Replicon chromosome
Accession NZ_CP098227
Organism Escherichia coli strain XJ6-3

Toxin (Protein)


Gene name yjhX Uniprot ID S1PA82
Locus tag KFZ54_RS20115 Protein ID WP_001054376.1
Coordinates 4174891..4175148 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name yjhQ Uniprot ID -
Locus tag KFZ54_RS20120 Protein ID WP_088375732.1
Coordinates 4175160..4175705 (+) Length 182 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KFZ54_RS20090 (4170179) 4170179..4171285 + 1107 WP_001309184.1 N-acetylneuraminate epimerase -
KFZ54_RS20095 (4171350) 4171350..4172330 + 981 WP_000991438.1 9-O-acetyl-N-acetylneuraminic acid deacetylase -
KFZ54_RS20100 (4172440) 4172440..4172645 + 206 Protein_3934 HNH endonuclease -
KFZ54_RS20105 (4172913) 4172913..4174153 - 1241 Protein_3935 helicase YjhR -
KFZ54_RS20110 (4174269) 4174269..4174400 + 132 WP_001309182.1 hypothetical protein -
KFZ54_RS20115 (4174891) 4174891..4175148 + 258 WP_001054376.1 YjhX family toxin Toxin
KFZ54_RS20120 (4175160) 4175160..4175705 + 546 WP_088375732.1 N-acetyltransferase Antitoxin
KFZ54_RS20125 (4175761) 4175761..4176507 + 747 WP_000354251.1 class I SAM-dependent methyltransferase -
KFZ54_RS20130 (4176676) 4176676..4176894 + 219 Protein_3940 hypothetical protein -
KFZ54_RS20135 (4176932) 4176932..4177048 + 117 Protein_3941 VOC family protein -
KFZ54_RS20140 (4177293) 4177293..4178414 + 1122 WP_000010829.1 M42 family metallopeptidase -
KFZ54_RS20145 (4178411) 4178411..4178689 + 279 WP_000722973.1 PTS sugar transporter subunit IIB SgcB -
KFZ54_RS20150 (4178701) 4178701..4180014 + 1314 WP_000460843.1 PTS sugar transporter subunit IIC SgcC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - fimI / fimA / fimE / fimB 4164677..4183929 19252


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Putative toxin of bacterial toxin-antitoxin pair

(1-85)

Antitoxin

GNAT domain

(18-121)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9734.29 Da        Isoelectric Point: 11.0090

>T247264 WP_001054376.1 NZ_CP098227:4174891-4175148 [Escherichia coli]
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTELNKVRA
QLDNR

Download         Length: 258 bp

Antitoxin


Download         Length: 182 a.a.        Molecular weight: 19926.87 Da        Isoelectric Point: 6.3277

>AT247264 WP_088375732.1 NZ_CP098227:4175160-4175705 [Escherichia coli]
MTVHHFTFHITDKSDASDIREVETRAFGFSKEADLVASLLEDESARPALSLLARYEGKAVGHILFTRAAFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCADPDETGALT

Download         Length: 546 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PA82

Antitoxin

Source ID Structure

References