Detailed information of TA system TA024726

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RHH(antitoxin)
• Location: 3739620..3740161
• Replicon: chromosome
• Accession: NC_014100
• Organism: Caulobacter segnis ATCC 21756

Toxin (Protein)

• Gene name: parE
• Uniprot ID: D5VMX2
• Locus tag: CSEG_RS17140
• Protein ID: WP_013080492.1
• Coordinates: 3739868..3740161 (+)
• Length: 98 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: D5VMX1
• Locus tag: CSEG_RS17135
• Protein ID: WP_013080491.1
• Coordinates: 3739620..3739871 (+)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CSEG_RS17110	3735049..3735651	-	603	WP_013080488.1	DUF4893 domain-containing protein	-
CSEG_RS17115	3735728..3736063	-	336	WP_083778494.1	response regulator	-
CSEG_RS17120	3736074..3737126	-	1053	WP_041538355.1	PAS domain S-box protein	-
CSEG_RS17125	3737298..3738416	-	1119	WP_013080489.1	DUF4167 domain-containing protein	-
CSEG_RS17130	3738662..3739531	-	870	WP_013080490.1	peptide chain release factor N(5)-glutamine methyltransferase	-
CSEG_RS17135	3739620..3739871	+	252	WP_013080491.1	type II toxin-antitoxin system ParD family antitoxin	Antitoxin
CSEG_RS17140	3739868..3740161	+	294	WP_013080492.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
CSEG_RS17145	3740153..3740914	-	762	WP_013080493.1	MOSC domain-containing protein	-
CSEG_RS17150	3741018..3742229	+	1212	WP_013080494.1	YihY/virulence factor BrkB family protein	-
CSEG_RS17155	3742226..3742756	-	531	WP_013080495.1	methyltransferase domain-containing protein	-
CSEG_RS17160	3742840..3743367	+	528	WP_013080496.1	GNAT family N-acetyltransferase	-
CSEG_RS17165	3743504..3744280	+	777	WP_013080497.1	hypothetical protein	-
CSEG_RS22690	3744290..3744410	+	121	Protein_3445	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-91)

Antitoxin

• Antitoxin ParD (4-72)

Sequences

Toxin

Protein

• Length: 98 a.a.
• Molecular weight: 11476.18 Da
• Isoelectric Point: 8.0351

>T24726 WP_013080492.1 NC_014100:3739868-3740161 [Caulobacter segnis ATCC 21756]
VSHYELTPLARFDMREIWTYTVRQWGRRVADGYIRDLSTTLEKIAREPYVGVAAEWIEEDCRKYVFRSHVIFYTPMKEGV
VVARILHQQMDAPSRLG

Nucleotide

• Length: 294 bp

>T24726 NC_014100:3739868-3740161 [Caulobacter segnis ATCC 21756]
GTGAGCCACTATGAGCTGACGCCGCTAGCGCGCTTCGATATGCGCGAAATCTGGACCTACACCGTTCGTCAATGGGGCCG
AAGGGTCGCCGACGGCTACATTCGCGACCTGTCCACCACGCTCGAAAAGATCGCCCGTGAACCTTACGTCGGCGTCGCTG
CGGAATGGATCGAAGAGGACTGCCGAAAGTACGTCTTTCGGTCCCACGTCATCTTCTATACGCCGATGAAGGAAGGTGTG
GTCGTCGCCCGTATACTCCATCAACAGATGGATGCACCAAGCCGCCTAGGTTAG

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9252.20 Da
• Isoelectric Point: 4.3992

>AT24726 WP_013080491.1 NC_014100:3739620-3739871 [Caulobacter segnis ATCC 21756]
MSKNTSIVLSEHFQSFITEKVEEGRYGSASEVVRAGLRLLEDHEAKLTALRTAVREGFESGKPEPFDVDTFLAEVNTDYD
AQS

Nucleotide

• Length: 252 bp

>AT24726 NC_014100:3739620-3739871 [Caulobacter segnis ATCC 21756]
ATGAGCAAGAACACCTCGATCGTCCTTAGTGAGCATTTTCAGTCCTTCATCACGGAGAAGGTCGAAGAGGGACGATATGG
CTCGGCGAGCGAGGTCGTTCGCGCCGGACTACGCCTGCTGGAGGATCACGAAGCCAAGCTCACGGCGCTCCGGACCGCCG
TGAGGGAAGGCTTTGAGAGCGGCAAGCCCGAGCCGTTCGATGTCGACACCTTCCTCGCGGAGGTCAACACGGACTACGAC
GCCCAGTCGTGA

Structures

Toxin

• AlphaFold DB: D5VMX2

Antitoxin

• AlphaFold DB: D5VMX1