Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) itaRT/DUF1778(antitoxin)
Location 3592412..3593249 Replicon chromosome
Accession NZ_CP098227
Organism Escherichia coli strain XJ6-3

Toxin (Protein)


Gene name itaT Uniprot ID A0A080JA52
Locus tag KFZ54_RS17365 Protein ID WP_032170811.1
Coordinates 3592707..3593249 (+) Length 181 a.a.

Antitoxin (Protein)


Gene name itaR Uniprot ID A0A080JFU1
Locus tag KFZ54_RS17360 Protein ID WP_001577859.1
Coordinates 3592412..3592723 (+) Length 104 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KFZ54_RS17335 (3587432) 3587432..3588379 + 948 WP_001239436.1 cytochrome o ubiquinol oxidase subunit II -
KFZ54_RS17340 (3588401) 3588401..3590392 + 1992 WP_000467180.1 cytochrome o ubiquinol oxidase subunit I -
KFZ54_RS17345 (3590382) 3590382..3590996 + 615 WP_000179819.1 cytochrome o ubiquinol oxidase subunit III -
KFZ54_RS17350 (3590996) 3590996..3591325 + 330 WP_000019869.1 cytochrome o ubiquinol oxidase subunit IV -
KFZ54_RS17355 (3591337) 3591337..3592227 + 891 WP_000971336.1 heme o synthase -
KFZ54_RS17360 (3592412) 3592412..3592723 + 312 WP_001577859.1 DUF1778 domain-containing protein Antitoxin
KFZ54_RS17365 (3592707) 3592707..3593249 + 543 WP_032170811.1 GNAT family N-acetyltransferase Toxin
KFZ54_RS17370 (3593305) 3593305..3594240 - 936 WP_045176456.1 tetratricopeptide repeat protein -
KFZ54_RS17375 (3594647) 3594647..3596011 + 1365 WP_001000956.1 MFS transporter -
KFZ54_RS17380 (3596139) 3596139..3596630 - 492 WP_001138904.1 nucleotide binding protein YajQ -
KFZ54_RS17385 (3596798) 3596798..3597709 + 912 WP_088375888.1 2-dehydropantoate 2-reductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - espY3 / espY3 3592412..3605830 13418


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(68-156)

Antitoxin

Vibrio phage ICP1, Orf50

(19-96)


Sequences

Toxin        


Download         Length: 181 a.a.        Molecular weight: 19835.05 Da        Isoelectric Point: 8.3395

>T247259 WP_032170811.1 NZ_CP098227:3592707-3593249 [Escherichia coli]
MVDKHEEITLPIVLSCNYQSDITYPGQKQFDCGNPVIDKFVRTSLKKSVRNSDCAAKALIDRQSGELIGICTFTAYSLEK
QRVSGVLQGSQPSEIGVVRLVMLGVARKYQKRGFGQDLLCDFFEHVKIIHQALPIKGVYLDADPAAINFYARLGFVQLSA
TPNAFGAVPMFLAIQHILAA

Download         Length: 543 bp

Antitoxin


Download         Length: 104 a.a.        Molecular weight: 11400.08 Da        Isoelectric Point: 10.5548

>AT247259 WP_001577859.1 NZ_CP098227:3592412-3592723 [Escherichia coli]
MPGKTATLPDVDKTLKNARVELKTSPDAKNRLREAAQAVGLDLSAFILSAAMERAESVLDNQRRRELSNQSWELMNQLIA
EPAQPTLALKALMKRKNSDGRQA

Download         Length: 312 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A080JA52

Antitoxin

Source ID Structure
AlphaFold DB A0A080JFU1

References