Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3547750..3548368 Replicon chromosome
Accession NZ_CP098227
Organism Escherichia coli strain XJ6-3

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag KFZ54_RS17140 Protein ID WP_001291435.1
Coordinates 3548150..3548368 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag KFZ54_RS17135 Protein ID WP_000344800.1
Coordinates 3547750..3548124 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KFZ54_RS17125 (3542839) 3542839..3544032 + 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
KFZ54_RS17130 (3544055) 3544055..3547204 + 3150 WP_001132469.1 efflux RND transporter permease AcrB -
KFZ54_RS17135 (3547750) 3547750..3548124 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
KFZ54_RS17140 (3548150) 3548150..3548368 + 219 WP_001291435.1 HHA domain-containing protein Toxin
KFZ54_RS17145 (3548540) 3548540..3549091 + 552 WP_000102564.1 maltose O-acetyltransferase -
KFZ54_RS17150 (3549207) 3549207..3549677 + 471 WP_000136192.1 YlaC family protein -
KFZ54_RS17155 (3549841) 3549841..3551391 + 1551 WP_021577088.1 cyclic-guanylate-specific phosphodiesterase PdeB -
KFZ54_RS17160 (3551433) 3551433..3551786 - 354 WP_000878140.1 DUF1428 domain-containing protein -
KFZ54_RS17165 (3552130) 3552130..3552357 - 228 WP_024183738.1 DUF2188 domain-containing protein -
KFZ54_RS17170 (3552575) 3552575..3553195 - 621 WP_001267012.1 recombinase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T247258 WP_001291435.1 NZ_CP098227:3548150-3548368 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT247258 WP_000344800.1 NZ_CP098227:3547750-3548124 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References