Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-HTH_XRE
Location 3135814..3136519 Replicon chromosome
Accession NZ_CP098227
Organism Escherichia coli strain XJ6-3

Toxin (Protein)


Gene name relE Uniprot ID A0A246P0D5
Locus tag KFZ54_RS15220 Protein ID WP_000539522.1
Coordinates 3135814..3136200 (+) Length 129 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag KFZ54_RS15225 Protein ID WP_001280945.1
Coordinates 3136190..3136519 (+) Length 110 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KFZ54_RS15200 (3131818) 3131818..3132444 + 627 WP_032280600.1 glutathione S-transferase GstB -
KFZ54_RS15205 (3132441) 3132441..3133556 - 1116 WP_032280599.1 aldose sugar dehydrogenase YliI -
KFZ54_RS15210 (3133667) 3133667..3134050 - 384 WP_000497137.1 biofilm formation regulator BssR -
KFZ54_RS15215 (3134263) 3134263..3135588 + 1326 WP_000049367.1 30S ribosomal protein S12 methylthiotransferase RimO -
KFZ54_RS15220 (3135814) 3135814..3136200 + 387 WP_000539522.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KFZ54_RS15225 (3136190) 3136190..3136519 + 330 WP_001280945.1 DNA-binding transcriptional regulator Antitoxin
KFZ54_RS15230 (3136589) 3136589..3137917 - 1329 WP_000086905.1 GGDEF domain-containing protein -
KFZ54_RS15235 (3137925) 3137925..3140273 - 2349 WP_028132100.1 EAL domain-containing protein -
KFZ54_RS15240 (3140451) 3140451..3141362 - 912 WP_001236044.1 glutathione ABC transporter permease GsiD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(1-124)

Antitoxin

Cro/C1-type helix-turn-helix domain

(53-94)


Sequences

Toxin        


Download         Length: 129 a.a.        Molecular weight: 14292.51 Da        Isoelectric Point: 10.2120

>T247257 WP_000539522.1 NZ_CP098227:3135814-3136200 [Escherichia coli]
MGVYKARRFSQSTKKLGIHDKVLMAAAEEVMQGIWEADLGSGVIKKRLPLQQGKSGGARTIIFFKSANHVFFYDGWSKSG
LSSKGTKEIEDDELAAYKKMANAFLAFSNKQIKDLIETGFLIEVKNER

Download         Length: 387 bp

Antitoxin


Download         Length: 110 a.a.        Molecular weight: 11982.08 Da        Isoelectric Point: 10.0101

>AT247257 WP_001280945.1 NZ_CP098227:3136190-3136519 [Escherichia coli]
MSDKLQMMLEDAKELNALGLMSDSEVDAIAVMVKAREVSARIAKVKSMTGEEIKAIRTRYGMSQSVLAHTMGMSKESVSK
WERNEIKPSGPALRILNTLAIKGPEVFAK

Download         Length: 330 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A246P0D5

Antitoxin

Source ID Structure

References