Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 877112..877766 Replicon chromosome
Accession NZ_CP098227
Organism Escherichia coli strain XJ6-3

Toxin (Protein)


Gene name cptA Uniprot ID S1EEB2
Locus tag KFZ54_RS04280 Protein ID WP_000244777.1
Coordinates 877359..877766 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag KFZ54_RS04275 Protein ID WP_000354046.1
Coordinates 877112..877378 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KFZ54_RS04250 (872400) 872400..873143 + 744 WP_088376394.1 SDR family oxidoreductase -
KFZ54_RS04255 (873200) 873200..874633 - 1434 WP_004993952.1 6-phospho-beta-glucosidase BglA -
KFZ54_RS04260 (874678) 874678..874989 + 312 WP_001182957.1 N(4)-acetylcytidine aminohydrolase -
KFZ54_RS04265 (875153) 875153..875812 + 660 WP_000250274.1 hemolysin III family protein -
KFZ54_RS04270 (875889) 875889..876869 - 981 WP_047644455.1 tRNA-modifying protein YgfZ -
KFZ54_RS04275 (877112) 877112..877378 + 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
KFZ54_RS04280 (877359) 877359..877766 + 408 WP_000244777.1 protein YgfX Toxin
KFZ54_RS04285 (877806) 877806..878327 - 522 WP_001055874.1 flavodoxin FldB -
KFZ54_RS04290 (878439) 878439..879335 + 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
KFZ54_RS04295 (879360) 879360..880070 + 711 WP_000715210.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
KFZ54_RS04300 (880076) 880076..881809 + 1734 WP_032288287.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16031.96 Da        Isoelectric Point: 11.5202

>T247248 WP_000244777.1 NZ_CP098227:877359-877766 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDGGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT247248 WP_000354046.1 NZ_CP098227:877112-877378 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LFV7

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References