Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ataRT/DUF1778(antitoxin)
Location 376082..376836 Replicon chromosome
Accession NZ_CP098227
Organism Escherichia coli strain XJ6-3

Toxin (Protein)


Gene name ataT Uniprot ID -
Locus tag KFZ54_RS01705 Protein ID WP_001301452.1
Coordinates 376082..376567 (-) Length 162 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID Q8X700
Locus tag KFZ54_RS01710 Protein ID WP_000801912.1
Coordinates 376558..376836 (-) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KFZ54_RS01685 (371249) 371249..372007 + 759 WP_000815099.1 DeoR/GlpR family transcriptional regulator -
KFZ54_RS01690 (371989) 371989..373587 - 1599 WP_088375916.1 DNA-binding transcriptional regulator RtcR -
KFZ54_RS01695 (373774) 373774..375000 + 1227 WP_001105483.1 RNA-splicing ligase RtcB -
KFZ54_RS01700 (375004) 375004..376032 + 1029 WP_097756021.1 RNA 3'-terminal phosphate cyclase -
KFZ54_RS01705 (376082) 376082..376567 - 486 WP_001301452.1 GNAT family N-acetyltransferase Toxin
KFZ54_RS01710 (376558) 376558..376836 - 279 WP_000801912.1 DUF1778 domain-containing protein Antitoxin
KFZ54_RS01715 (376903) 376903..379608 - 2706 WP_097756020.1 HTH-type transcriptional regulator MalT -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(45-143)

Antitoxin

Vibrio phage ICP1, Orf50

(2-92)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17650.57 Da        Isoelectric Point: 9.4066

>T247246 WP_001301452.1 NZ_CP098227:c376567-376082 [Escherichia coli]
MGITAPTPLTSEHNLADFCCSDHGMNEWLKKKALKNHSSGLSRVYVICIANTRQVIGYYCLSTGSIQRNLAPGAMRRNAP
ESLPVVVLGRLAIDQAWAGKGLGVALLKDAVYRTMSIAQQVGVRALIVHALDDSVRNFYLKYAFVPSPFQSLTLLYPITL
E

Download         Length: 486 bp

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10420.94 Da        Isoelectric Point: 4.6336

>AT247246 WP_000801912.1 NZ_CP098227:c376836-376558 [Escherichia coli]
MKPESKEAPINIRAKASQRDLIDMAANLVAKSRTDFMLDAACREAQDILLDQRLFILDDEQYDAFLAALDAPITAERQAK
INALMNRKSPWE

Download         Length: 279 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LHB9

References