Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 4623431..4624043 Replicon chromosome
Accession NZ_CP098223
Organism Escherichia coli strain Z0117EC0005

Toxin (Protein)


Gene name hicA Uniprot ID U9YXE2
Locus tag NBY12_RS22185 Protein ID WP_000833473.1
Coordinates 4623858..4624043 (-) Length 62 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID L4IWR9
Locus tag NBY12_RS22180 Protein ID WP_000499744.1
Coordinates 4623431..4623841 (-) Length 137 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NBY12_RS22155 (4619637) 4619637..4620377 - 741 WP_000906829.1 MipA/OmpV family protein -
NBY12_RS22160 (4620501) 4620501..4621475 + 975 WP_000164020.1 LysR family transcriptional regulator -
NBY12_RS22165 (4621472) 4621472..4622608 - 1137 WP_000364885.1 HlyD family secretion protein -
NBY12_RS22170 (4622614) 4622614..4622937 - 324 WP_000478193.1 DUF3302 domain-containing protein -
NBY12_RS22175 (4623108) 4623108..4623434 + 327 WP_129707915.1 hypothetical protein -
NBY12_RS22180 (4623431) 4623431..4623841 - 411 WP_000499744.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
NBY12_RS22185 (4623858) 4623858..4624043 - 186 WP_000833473.1 type II toxin-antitoxin system HicA family toxin Toxin
NBY12_RS22190 (4624321) 4624321..4625859 - 1539 WP_000183978.1 aldehyde dehydrogenase AldB -
NBY12_RS22195 (4626060) 4626060..4627211 - 1152 WP_000741501.1 L-threonine dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-129)


Sequences

Toxin        


Download         Length: 62 a.a.        Molecular weight: 6800.89 Da        Isoelectric Point: 11.7053

>T247240 WP_000833473.1 NZ_CP098223:c4624043-4623858 [Escherichia coli]
VKSADVIAILKQHGWEHIRTRGSHHQFRHPVHPGLVTVPHPKKDIKPGTLAQIGRQAGLTF

Download         Length: 186 bp

Antitoxin


Download         Length: 137 a.a.        Molecular weight: 15241.15 Da        Isoelectric Point: 4.5486

>AT247240 WP_000499744.1 NZ_CP098223:c4623841-4623431 [Escherichia coli]
MFYPAYIHSDPDGSASGFFPDVPGCYFAGDTLDNAFQDARSALVAHFETLCEMNEELPLPGSVETHLVQRAQDFIGGQWL
LVDINMNQFEGRAERINITMPKRLLNKIDTYVRNNPDYANRSAFLAEAARRVLPGV

Download         Length: 411 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9YXE2

Antitoxin

Source ID Structure
AlphaFold DB L4IWR9

References