Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3856017..3856671 Replicon chromosome
Accession NZ_CP098223
Organism Escherichia coli strain Z0117EC0005

Toxin (Protein)


Gene name cptA Uniprot ID S1PAM6
Locus tag NBY12_RS18370 Protein ID WP_000244781.1
Coordinates 3856017..3856424 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag NBY12_RS18375 Protein ID WP_000354046.1
Coordinates 3856405..3856671 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NBY12_RS18350 (3851974) 3851974..3853707 - 1734 WP_032303735.1 single-stranded-DNA-specific exonuclease RecJ -
NBY12_RS18355 (3853713) 3853713..3854423 - 711 WP_000715213.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
NBY12_RS18360 (3854448) 3854448..3855344 - 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
NBY12_RS18365 (3855456) 3855456..3855977 + 522 WP_032303736.1 flavodoxin FldB -
NBY12_RS18370 (3856017) 3856017..3856424 - 408 WP_000244781.1 protein YgfX Toxin
NBY12_RS18375 (3856405) 3856405..3856671 - 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
NBY12_RS18380 (3856923) 3856923..3857903 + 981 WP_032303737.1 tRNA-modifying protein YgfZ -
NBY12_RS18385 (3857930) 3857930..3859228 + 1299 WP_050486624.1 hypothetical protein -
NBY12_RS18390 (3859225) 3859225..3859692 + 468 WP_032303738.1 hypothetical protein -
NBY12_RS18395 (3859723) 3859723..3860382 - 660 WP_000250274.1 hemolysin III family protein -
NBY12_RS18400 (3860546) 3860546..3860857 - 312 WP_001182966.1 N(4)-acetylcytidine aminohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16061.99 Da        Isoelectric Point: 11.5202

>T247234 WP_000244781.1 NZ_CP098223:c3856424-3856017 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDSGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT247234 WP_000354046.1 NZ_CP098223:c3856671-3856405 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PAM6

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References