Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 2721518..2722113 Replicon chromosome
Accession NC_014098
Organism Kyrpidia tusciae DSM 2912

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag BTUS_RS13490 Protein ID WP_041306106.1
Coordinates 2721853..2722113 (-) Length 87 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag BTUS_RS13485 Protein ID WP_041304338.1
Coordinates 2721518..2721853 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BTUS_RS13455 2716990..2717565 + 576 WP_013076621.1 hypothetical protein -
BTUS_RS13460 2717567..2718877 + 1311 WP_083780210.1 beta-N-acetylhexosaminidase -
BTUS_RS13465 2719113..2719511 + 399 WP_013076623.1 GntR family transcriptional regulator -
BTUS_RS13470 2719508..2720206 + 699 WP_013076624.1 ABC transporter ATP-binding protein -
BTUS_RS13475 2720220..2720975 + 756 WP_013076625.1 ABC transporter permease subunit -
BTUS_RS13485 2721518..2721853 - 336 WP_041304338.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
BTUS_RS13490 2721853..2722113 - 261 WP_041306106.1 type II toxin-antitoxin system HicA family toxin Toxin
BTUS_RS13495 2722263..2722454 - 192 WP_041304340.1 hypothetical protein -
BTUS_RS13500 2722787..2723725 - 939 WP_013076630.1 amidohydrolase family protein -
BTUS_RS13505 2723745..2725391 - 1647 WP_013076631.1 bacillithiol biosynthesis cysteine-adding enzyme BshC -
BTUS_RS13510 2725529..2726002 - 474 WP_013076632.1 DinB family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(25-83)

Antitoxin

Uncharacterised protein family HicB

(51-99)


Sequences

Toxin        


Download         Length: 87 a.a.        Molecular weight: 9442.95 Da        Isoelectric Point: 10.7588

>T24723 WP_041306106.1 NC_014098:c2722113-2721853 [Kyrpidia tusciae DSM 2912]
ILLNKKHLVTLRSVFEDPVRADIVWSDVESMLVALGADVSEGKGSRVRVALNGVRAVFHRPHPQKETGKGAVKSLRRFLT
EAGVEP

Download         Length: 261 bp

>T24723 NC_014098:c2722113-2721853 [Kyrpidia tusciae DSM 2912]
ATACTACTGAACAAAAAACATCTTGTGACGCTCCGGTCTGTTTTTGAGGATCCGGTTCGCGCCGACATTGTCTGGTCCGA
CGTCGAATCGATGCTTGTGGCCCTTGGGGCGGATGTGTCCGAGGGGAAGGGTTCCCGTGTCCGGGTTGCACTGAACGGAG
TCAGAGCCGTTTTCCACCGTCCGCATCCGCAAAAGGAAACGGGCAAAGGCGCCGTGAAATCCTTGCGAAGATTCTTAACC
GAGGCGGGTGTCGAGCCTTGA

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12706.02 Da        Isoelectric Point: 4.6909

>AT24723 WP_041304338.1 NC_014098:c2721853-2721518 [Kyrpidia tusciae DSM 2912]
MEYKGYQARVEFDDESGVFHGEVINTRDVITFQGQSVEELRQAFRDSVDDYLAYCAERGEEPEKPFSGRFVLRLTPEQHR
LAALAARRSGKSLNAWIAEHIDEDARRELGG

Download         Length: 336 bp

>AT24723 NC_014098:c2721853-2721518 [Kyrpidia tusciae DSM 2912]
ATGGAGTATAAAGGGTATCAAGCGCGGGTTGAATTCGACGATGAGAGCGGCGTATTTCATGGTGAGGTGATCAACACCAG
AGATGTGATTACCTTTCAGGGTCAGTCGGTCGAAGAACTGCGTCAGGCGTTTAGGGATTCGGTGGATGATTATCTCGCGT
ATTGTGCCGAACGAGGGGAAGAGCCTGAAAAACCTTTTTCCGGGCGATTCGTTCTTCGCTTGACGCCGGAGCAGCATCGG
TTGGCTGCTTTGGCGGCCCGTCGGTCGGGAAAGAGCTTGAACGCCTGGATCGCTGAGCATATTGACGAAGACGCTCGAAG
AGAACTCGGCGGTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References