Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1257255..1257873 Replicon chromosome
Accession NZ_CP098223
Organism Escherichia coli strain Z0117EC0005

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag NBY12_RS06010 Protein ID WP_001291435.1
Coordinates 1257255..1257473 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag NBY12_RS06015 Protein ID WP_000344800.1
Coordinates 1257499..1257873 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NBY12_RS05975 (1252544) 1252544..1253116 + 573 WP_032302581.1 YbaY family lipoprotein -
NBY12_RS05980 (1253147) 1253147..1253458 - 312 WP_000409907.1 MGMT family protein -
NBY12_RS05990 (1253837) 1253837..1254190 + 354 WP_000878140.1 DUF1428 domain-containing protein -
NBY12_RS05995 (1254232) 1254232..1255782 - 1551 WP_001353400.1 cyclic-guanylate-specific phosphodiesterase PdeB -
NBY12_RS06000 (1255946) 1255946..1256416 - 471 WP_000136192.1 YlaC family protein -
NBY12_RS06005 (1256532) 1256532..1257083 - 552 WP_032302582.1 maltose O-acetyltransferase -
NBY12_RS06010 (1257255) 1257255..1257473 - 219 WP_001291435.1 HHA domain-containing protein Toxin
NBY12_RS06015 (1257499) 1257499..1257873 - 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
NBY12_RS06020 (1258420) 1258420..1261569 - 3150 WP_001132494.1 efflux RND transporter permease AcrB -
NBY12_RS06025 (1261592) 1261592..1262785 - 1194 WP_001353399.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T247221 WP_001291435.1 NZ_CP098223:c1257473-1257255 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT247221 WP_000344800.1 NZ_CP098223:c1257873-1257499 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References