Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN-PHD
Location 883413..884032 Replicon chromosome
Accession NC_014098
Organism Kyrpidia tusciae DSM 2912

Toxin (Protein)


Gene name vapC Uniprot ID D5WW05
Locus tag BTUS_RS04495 Protein ID WP_013074929.1
Coordinates 883646..884032 (+) Length 129 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID D5WW04
Locus tag BTUS_RS04490 Protein ID WP_013074928.1
Coordinates 883413..883649 (+) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BTUS_RS04475 879942..881150 + 1209 WP_013074925.1 spore photoproduct lyase -
BTUS_RS04480 881147..883102 - 1956 WP_013074926.1 PepSY domain-containing protein -
BTUS_RS04490 883413..883649 + 237 WP_013074928.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
BTUS_RS04495 883646..884032 + 387 WP_013074929.1 type II toxin-antitoxin system VapC family toxin Toxin
BTUS_RS04500 884427..885434 - 1008 WP_013074930.1 GTP-binding protein -
BTUS_RS04505 885448..885786 - 339 WP_013074931.1 hypothetical protein -
BTUS_RS04510 885866..886750 - 885 WP_013074932.1 polysaccharide deacetylase -
BTUS_RS04515 886775..887740 - 966 WP_013074933.1 asparaginase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

VapC-like Sll0205 protein, PIN domain

(4-128)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(3-44)


Sequences

Toxin        


Download         Length: 129 a.a.        Molecular weight: 14817.08 Da        Isoelectric Point: 4.5959

>T24722 WP_013074929.1 NC_014098:883646-884032 [Kyrpidia tusciae DSM 2912]
MKTLLDTHVFLWWITDDGRMSKRARAIIQDTRNELYLSAASAWEIAIKAALGRIRVYEDLDRFMTQQMNENGIVDLPVEI
LHALGVYGLPDLHRDPFDRLLVAQAIQEGMPVITADEWIKCYDVETIW

Download         Length: 387 bp

>T24722 NC_014098:883646-884032 [Kyrpidia tusciae DSM 2912]
ATGAAGACCCTTCTTGATACGCACGTCTTCCTGTGGTGGATCACCGATGATGGGCGGATGTCCAAACGTGCAAGAGCGAT
TATCCAAGATACAAGGAATGAACTGTATTTAAGTGCGGCGAGTGCCTGGGAGATCGCGATCAAAGCCGCCCTCGGCCGAA
TACGCGTATACGAAGATTTGGACCGGTTCATGACCCAGCAGATGAACGAAAACGGTATTGTGGATTTGCCCGTCGAGATT
CTCCATGCGCTCGGGGTCTATGGGCTTCCGGATTTGCACCGCGACCCGTTTGACCGCCTTTTGGTCGCCCAAGCCATACA
AGAAGGCATGCCCGTCATCACCGCGGATGAGTGGATCAAGTGTTATGATGTTGAGACGATCTGGTGA

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8746.21 Da        Isoelectric Point: 10.2014

>AT24722 WP_013074928.1 NC_014098:883413-883649 [Kyrpidia tusciae DSM 2912]
VTKVVNVHEAKTHFSKLLARVEVGEEIVIAKAGKPLARLVPYRERPTKRVPGTAKSLIVVGEDFDDPLPESIQRLFER

Download         Length: 237 bp

>AT24722 NC_014098:883413-883649 [Kyrpidia tusciae DSM 2912]
GTGACCAAAGTGGTCAACGTCCACGAGGCAAAGACGCATTTTTCAAAACTATTGGCGCGTGTAGAAGTCGGGGAAGAGAT
CGTCATCGCGAAAGCGGGTAAACCCCTCGCCCGGCTCGTGCCTTATCGCGAACGGCCGACAAAGCGCGTACCGGGCACAG
CCAAAAGTCTAATTGTTGTCGGGGAAGATTTTGACGATCCGCTGCCGGAGTCGATTCAGAGGTTGTTCGAACGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB D5WW05

Antitoxin

Source ID Structure
AlphaFold DB A0A6F9E101

References