Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | mosAT/AbiEii-AbiEi |
| Location | 1033067..1034756 | Replicon | chromosome |
| Accession | NZ_CP098223 | ||
| Organism | Escherichia coli strain Z0117EC0005 | ||
Toxin (Protein)
| Gene name | mosT | Uniprot ID | A0A2K3TY15 |
| Locus tag | NBY12_RS04975 | Protein ID | WP_032302488.1 |
| Coordinates | 1033836..1034756 (+) | Length | 307 a.a. |
Antitoxin (Protein)
| Gene name | mosA | Uniprot ID | - |
| Locus tag | NBY12_RS04970 | Protein ID | WP_032302487.1 |
| Coordinates | 1033067..1033849 (+) | Length | 261 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| NBY12_RS04950 (1028376) | 1028376..1028578 | - | 203 | Protein_949 | integrase | - |
| NBY12_RS04955 (1028625) | 1028625..1028727 | - | 103 | Protein_950 | helix-turn-helix domain-containing protein | - |
| NBY12_RS04960 (1028724) | 1028724..1029194 | - | 471 | WP_000201186.1 | hypothetical protein | - |
| NBY12_RS04965 (1029541) | 1029541..1032750 | - | 3210 | WP_250777573.1 | hypothetical protein | - |
| NBY12_RS04970 (1033067) | 1033067..1033849 | + | 783 | WP_032302487.1 | type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein | Antitoxin |
| NBY12_RS04975 (1033836) | 1033836..1034756 | + | 921 | WP_032302488.1 | nucleotidyl transferase AbiEii/AbiGii toxin family protein | Toxin |
| NBY12_RS04980 (1034919) | 1034919..1035011 | - | 93 | Protein_955 | small membrane protein YkgR | - |
| NBY12_RS04985 (1035217) | 1035217..1036101 | - | 885 | WP_001119037.1 | LysR family transcriptional regulator | - |
| NBY12_RS04990 (1036366) | 1036366..1037424 | + | 1059 | WP_123058987.1 | alpha/beta hydrolase | - |
| NBY12_RS04995 (1037566) | 1037566..1038693 | + | 1128 | WP_032302489.1 | MFS transporter | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 307 a.a. Molecular weight: 34721.06 Da Isoelectric Point: 6.9552
>T247219 WP_032302488.1 NZ_CP098223:1033836-1034756 [Escherichia coli]
MDLRDSYTRQVKLLMAALPHVAKESCFALKGGTAINLFVQDFPRLSVDIDLAYKTFADRDTDLTAINDSLKRITASLNSK
PGITAIRQENKTDEKRIIVNTADAQIKIEVSPVWRGLLLPPAEMSVCERVEMEYGFTTMSVVSLADLYGGKICAALDRQH
PRDLFDVLNMLEKPGLMREIFDGFLCYLAGHPRPIAELLAPNWDTERITTLYAQEFSGMTQQETSLESLLSVTTLLPQAL
KSHLTDLDREFLLSFKQNSPDWSRYRYPEIQHFPAIRWKQRNLAVLKDKNPAKYVAAVNKLERVLA
MDLRDSYTRQVKLLMAALPHVAKESCFALKGGTAINLFVQDFPRLSVDIDLAYKTFADRDTDLTAINDSLKRITASLNSK
PGITAIRQENKTDEKRIIVNTADAQIKIEVSPVWRGLLLPPAEMSVCERVEMEYGFTTMSVVSLADLYGGKICAALDRQH
PRDLFDVLNMLEKPGLMREIFDGFLCYLAGHPRPIAELLAPNWDTERITTLYAQEFSGMTQQETSLESLLSVTTLLPQAL
KSHLTDLDREFLLSFKQNSPDWSRYRYPEIQHFPAIRWKQRNLAVLKDKNPAKYVAAVNKLERVLA
Download Length: 921 bp
Antitoxin
Download Length: 261 a.a. Molecular weight: 29161.41 Da Isoelectric Point: 7.7748
>AT247219 WP_032302487.1 NZ_CP098223:1033067-1033849 [Escherichia coli]
MPNYLNWLMQHTLPGQVLLQSWLTRNGVDRKLSYLYVQNGWLRRIAHGVYCRTGREPDWVDAVYCLQTQWEKPVRVAGLT
SLALQGHAHYTEPGKPQVWLALPAYVKLPGWFAAFEQSATFITLYTSGLTVDVTSLTTELKIGDRQLAGSVPELAAYEIA
CGVPSLISFEHADALFQGLNLLSPRKLQALLRASHSIKTNRVMLYLARRNGHPYFQYLDQSGIETGTGKRQIIPGGWLEP
DYQITVPCEFKPEGVEDGSA
MPNYLNWLMQHTLPGQVLLQSWLTRNGVDRKLSYLYVQNGWLRRIAHGVYCRTGREPDWVDAVYCLQTQWEKPVRVAGLT
SLALQGHAHYTEPGKPQVWLALPAYVKLPGWFAAFEQSATFITLYTSGLTVDVTSLTTELKIGDRQLAGSVPELAAYEIA
CGVPSLISFEHADALFQGLNLLSPRKLQALLRASHSIKTNRVMLYLARRNGHPYFQYLDQSGIETGTGKRQIIPGGWLEP
DYQITVPCEFKPEGVEDGSA
Download Length: 783 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|