Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 198616..199269 Replicon chromosome
Accession NC_014098
Organism Kyrpidia tusciae DSM 2912

Toxin (Protein)


Gene name mazF Uniprot ID D5WSA7
Locus tag BTUS_RS01105 Protein ID WP_013074285.1
Coordinates 198919..199269 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A2K8N2G8
Locus tag BTUS_RS01100 Protein ID WP_041303528.1
Coordinates 198616..198915 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BTUS_RS01080 193835..194227 + 393 WP_013074280.1 holo-ACP synthase -
BTUS_RS01085 194425..195936 + 1512 WP_013074281.1 NAD(P)H-hydrate dehydratase -
BTUS_RS01090 196011..197009 + 999 WP_013074282.1 outer membrane lipoprotein carrier protein LolA -
BTUS_RS01095 197020..198111 - 1092 WP_013074283.1 cation diffusion facilitator family transporter -
BTUS_RS01100 198616..198915 + 300 WP_041303528.1 CopG family ribbon-helix-helix protein Antitoxin
BTUS_RS01105 198919..199269 + 351 WP_013074285.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
BTUS_RS01110 199328..200587 + 1260 WP_013074286.1 adenosylhomocysteinase -
BTUS_RS01115 200744..201481 + 738 WP_013074287.1 gamma-glutamyl-gamma-aminobutyrate hydrolase family protein -
BTUS_RS01120 201801..202022 + 222 WP_013074288.1 DUF1659 domain-containing protein -
BTUS_RS01125 202058..202291 + 234 WP_013074289.1 DUF2922 domain-containing protein -
BTUS_RS01130 202385..202681 - 297 WP_041303530.1 zf-TFIIB domain-containing protein -
BTUS_RS01135 202796..203389 - 594 WP_013074291.1 DedA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-113)

Antitoxin

Ribbon-helix-helix protein, CopG

(15-53)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12906.94 Da        Isoelectric Point: 5.6976

>T24721 WP_013074285.1 NC_014098:198919-199269 [Kyrpidia tusciae DSM 2912]
VNIKRGDIFFANLSPVVGSEQGGFRPVLVIQNDIGNRFSPTVIVAAITAQIQKAKLPTHVEIDAKTYGLDRDSVILLEQI
RTIDKQRLTDKITHLDDEMMSKVNESLMISLGLIDF

Download         Length: 351 bp

>T24721 NC_014098:198919-199269 [Kyrpidia tusciae DSM 2912]
GTGAACATCAAGCGAGGGGATATTTTTTTTGCGAATCTATCCCCGGTGGTCGGTTCTGAGCAAGGGGGCTTCCGGCCGGT
ATTGGTGATCCAAAACGATATCGGAAACCGGTTTAGCCCGACAGTCATCGTCGCGGCAATCACCGCCCAGATTCAGAAGG
CTAAGCTGCCCACCCACGTGGAGATTGATGCGAAGACCTACGGCCTGGATCGGGATTCGGTCATCCTCCTGGAACAGATT
CGCACCATTGATAAGCAGCGGTTGACGGATAAGATCACGCACCTGGATGATGAGATGATGAGCAAGGTCAACGAGTCGCT
CATGATCAGCCTGGGGTTGATCGATTTTTAG

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 11329.99 Da        Isoelectric Point: 4.9577

>AT24721 WP_041303528.1 NC_014098:198616-198915 [Kyrpidia tusciae DSM 2912]
MASVPEVLGLSETKRIMISVPSHLLQEVDGIAERENSNRSEVIRQAMRLYLEERKKERIRELMQRGYVEMAKINLYIASE
AFYAEEEAGSTLDRLVSGV

Download         Length: 300 bp

>AT24721 NC_014098:198616-198915 [Kyrpidia tusciae DSM 2912]
ATGGCGAGTGTCCCGGAGGTGCTTGGGTTGTCCGAAACAAAGCGGATTATGATTAGTGTTCCGAGTCACCTGCTCCAGGA
AGTCGACGGAATTGCAGAAAGAGAGAATTCCAATCGAAGCGAGGTCATTCGCCAAGCGATGAGATTGTATTTGGAAGAGC
GTAAAAAGGAACGCATTCGCGAGTTGATGCAGCGGGGTTATGTGGAGATGGCGAAGATTAACCTTTATATTGCGTCGGAG
GCGTTTTACGCCGAAGAGGAGGCGGGTTCGACCCTAGATCGACTAGTAAGCGGGGTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2K8N5K4

Antitoxin

Source ID Structure
AlphaFold DB A0A2K8N2G8

References