Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ataRT/DUF1778(antitoxin)
Location 4574661..4575461 Replicon chromosome
Accession NZ_CP098219
Organism Escherichia coli strain Z0117EC0013

Toxin (Protein)


Gene name ataT Uniprot ID F4T503
Locus tag NBY13_RS22135 Protein ID WP_000342452.1
Coordinates 4574661..4575188 (-) Length 176 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID F4T504
Locus tag NBY13_RS22140 Protein ID WP_001277107.1
Coordinates 4575195..4575461 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NBY13_RS22110 (4569737) 4569737..4570504 - 768 WP_000082101.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG -
NBY13_RS22115 (4570501) 4570501..4571778 - 1278 WP_000803819.1 branched chain amino acid ABC transporter permease LivM -
NBY13_RS22120 (4571775) 4571775..4572701 - 927 WP_001295097.1 high-affinity branched-chain amino acid ABC transporter permease LivH -
NBY13_RS22125 (4572749) 4572749..4573858 - 1110 WP_001296485.1 high-affinity branched-chain amino acid ABC transporter substrate-binding protein LivK -
NBY13_RS22130 (4574281) 4574281..4574664 + 384 WP_000778796.1 aspartate 1-decarboxylase autocleavage activator PanM -
NBY13_RS22135 (4574661) 4574661..4575188 - 528 WP_000342452.1 type II toxin-antitoxin system toxin acetyltransferase AtaT Toxin
NBY13_RS22140 (4575195) 4575195..4575461 - 267 WP_001277107.1 type II toxin-antitoxin system antitoxin AtaR Antitoxin
NBY13_RS22145 (4575610) 4575610..4576713 - 1104 WP_001021994.1 branched chain amino acid ABC transporter substrate-binding protein LivJ -
NBY13_RS22150 (4576984) 4576984..4577838 - 855 WP_000130217.1 RNA polymerase sigma factor RpoH -
NBY13_RS22155 (4578083) 4578083..4579141 - 1059 WP_001042003.1 permease-like cell division protein FtsX -
NBY13_RS22160 (4579134) 4579134..4579802 - 669 WP_000617723.1 cell division ATP-binding protein FtsE -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(88-150)

Antitoxin

Vibrio phage ICP1, Orf50

(8-86)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19673.57 Da        Isoelectric Point: 6.6348

>T247201 WP_000342452.1 NZ_CP098219:c4575188-4574661 [Escherichia coli]
MDDLTIEILTDDADYDLQRFDCGEEALNLFLTTHLVRQHRNKILRAYILCRNTPERQVLGYYTLSGSCFERAALPSKSKQ
KKIPYKNIPSVTLGRLAIDRSLQGQGWGATLVAHAMKVVWSASLAVGIHGLFVEALNEKAHTFYQSLGFIPLVGENENAL
FFPTKSIELLFTPDD

Download         Length: 528 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9929.38 Da        Isoelectric Point: 10.0863

>AT247201 WP_001277107.1 NZ_CP098219:c4575461-4575195 [Escherichia coli]
MSAVKKQRIDLRLTDDDKSMIEEAAAISNQSVSQFMLNSASQRAAEVIEQHRRMILTEESWTRVMDALSNPPSPGEKLKR
AAKRLQGM

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A061K5K9

Antitoxin

Source ID Structure
AlphaFold DB A0A061YQ57

References