Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3894430..3895084 Replicon chromosome
Accession NZ_CP098219
Organism Escherichia coli strain Z0117EC0013

Toxin (Protein)


Gene name cptA Uniprot ID F4T2L4
Locus tag NBY13_RS18720 Protein ID WP_000244765.1
Coordinates 3894430..3894837 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID F4T2L5
Locus tag NBY13_RS18725 Protein ID WP_000354050.1
Coordinates 3894818..3895084 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NBY13_RS18700 (3890387) 3890387..3892120 - 1734 WP_000813195.1 single-stranded-DNA-specific exonuclease RecJ -
NBY13_RS18705 (3892126) 3892126..3892836 - 711 WP_000715230.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
NBY13_RS18710 (3892861) 3892861..3893757 - 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
NBY13_RS18715 (3893869) 3893869..3894390 + 522 WP_001055874.1 flavodoxin FldB -
NBY13_RS18720 (3894430) 3894430..3894837 - 408 WP_000244765.1 protein YgfX Toxin
NBY13_RS18725 (3894818) 3894818..3895084 - 267 WP_000354050.1 FAD assembly factor SdhE Antitoxin
NBY13_RS18730 (3895327) 3895327..3896307 + 981 WP_000886080.1 tRNA-modifying protein YgfZ -
NBY13_RS18735 (3896384) 3896384..3897043 - 660 WP_000250275.1 hemolysin III family protein -
NBY13_RS18740 (3897207) 3897207..3897518 - 312 WP_001182956.1 N(4)-acetylcytidine aminohydrolase -
NBY13_RS18745 (3897563) 3897563..3898996 + 1434 WP_001296350.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16043.95 Da        Isoelectric Point: 11.5202

>T247197 WP_000244765.1 NZ_CP098219:c3894837-3894430 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLIPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDSGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10535.07 Da        Isoelectric Point: 5.1599

>AT247197 WP_000354050.1 NZ_CP098219:c3895084-3894818 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRTFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A454A7D7

Antitoxin

Source ID Structure
AlphaFold DB A0A061L3F4

References