Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1322305..1322923 Replicon chromosome
Accession NZ_CP098219
Organism Escherichia coli strain Z0117EC0013

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag NBY13_RS06210 Protein ID WP_001291435.1
Coordinates 1322305..1322523 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag NBY13_RS06215 Protein ID WP_000344800.1
Coordinates 1322549..1322923 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NBY13_RS06175 (1317593) 1317593..1318165 + 573 WP_000779841.1 YbaY family lipoprotein -
NBY13_RS06180 (1318196) 1318196..1318507 - 312 WP_000409908.1 MGMT family protein -
NBY13_RS06190 (1318886) 1318886..1319239 + 354 WP_000878147.1 DUF1428 family protein -
NBY13_RS06195 (1319281) 1319281..1320831 - 1551 WP_001545832.1 cyclic-guanylate-specific phosphodiesterase PdeB -
NBY13_RS06200 (1320995) 1320995..1321465 - 471 WP_000136192.1 YlaC family protein -
NBY13_RS06205 (1321581) 1321581..1322132 - 552 WP_000102539.1 maltose O-acetyltransferase -
NBY13_RS06210 (1322305) 1322305..1322523 - 219 WP_001291435.1 HHA domain-containing protein Toxin
NBY13_RS06215 (1322549) 1322549..1322923 - 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
NBY13_RS06220 (1323469) 1323469..1326618 - 3150 WP_001132478.1 efflux RND transporter permease AcrB -
NBY13_RS06225 (1326641) 1326641..1327834 - 1194 WP_001295833.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T247184 WP_001291435.1 NZ_CP098219:c1322523-1322305 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT247184 WP_000344800.1 NZ_CP098219:c1322923-1322549 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References