Detailed information of TA system TA247183

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mosAT/AbiEii-AbiEi
• Location: 1137945..1139634
• Replicon: chromosome
• Accession: NZ_CP098219
• Organism: Escherichia coli strain Z0117EC0013

Toxin (Protein)

• Gene name: mosT
• Uniprot ID: A0A061KTE0
• Locus tag: NBY13_RS05345
• Protein ID: WP_000365807.1
• Coordinates: 1138714..1139634 (+)
• Length: 307 a.a.

Antitoxin (Protein)

• Gene name: mosA
• Uniprot ID: -
• Locus tag: NBY13_RS05340
• Protein ID: WP_001295795.1
• Coordinates: 1137945..1138727 (+)
• Length: 261 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
NBY13_RS05335 (1134563)	1134563..1137661	-	3099	WP_000673070.1	type I restriction endonuclease	-
NBY13_RS05340 (1137945)	1137945..1138727	+	783	WP_001295795.1	type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein	Antitoxin
NBY13_RS05345 (1138714)	1138714..1139634	+	921	WP_000365807.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
NBY13_RS05350 (1139799)	1139799..1140575	-	777	WP_000171155.1	site-specific integrase	-
NBY13_RS05355 (1140783)	1140783..1141118	-	336	WP_000996167.1	Arm DNA-binding domain-containing protein	-
NBY13_RS05360 (1141345)	1141345..1141503	-	159	Protein_1029	integrase	-
NBY13_RS05365 (1141552)	1141552..1141737	+	186	WP_000146240.1	hypothetical protein	-
NBY13_RS05370 (1141952)	1141952..1142566	+	615	WP_001019923.1	YagU family protein	-
NBY13_RS05375 (1142637)	1142637..1142803	+	167	Protein_1032	tail fiber assembly protein	-
NBY13_RS05380 (1142815)	1142815..1143144	-	330	WP_001295797.1	YkgJ family cysteine cluster protein	-
NBY13_RS05385 (1143451)	1143451..1144161	-	711	WP_001295798.1	fimbrial chaperone EcpE	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	yagV/ecpE / yagW/ecpD / yagX/ecpC / yagY/ecpB / yagZ/ecpA / ykgK/ecpR / fdeC	1130882..1179847	48965

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (14-223)

Antitoxin

• Transcriptional regulator AbiEi antitoxin, N-terminal domain (3-90)

Sequences

Toxin

Protein

• Length: 307 a.a.
• Molecular weight: 34570.89 Da
• Isoelectric Point: 7.3239

>T247183 WP_000365807.1 NZ_CP098219:1138714-1139634 [Escherichia coli]
MDLRDSYARQVKLLMAALPHVAKESCFALKGGTAINLFVQDFPRLSVDIDLAYKSFADRDTDLAAINDALKRITASLNGR
PGITAIRQENKADEKRIIVNTADAKIKIEVSPVWRGLLLPPAEMPVCERVEMEYGFTTMSVVSLADLYGGKICAALDRQH
PRDLFDVLNMLGRPGLTREIFDGFLCYLAGHPRPIAELLASNWDTDRIATLYAQEFSGMTQQETSLESLLSVTTLLPQAL
KSHFTDLDREFLLSFKQNSPDWSRYRYPEIQHLPAIRWKQRNLAMLKDKNPAKYVAAVNKLERVLE

Nucleotide

• Length: 921 bp

Antitoxin

Protein

• Length: 261 a.a.
• Molecular weight: 29099.24 Da
• Isoelectric Point: 8.5975

>AT247183 WP_001295795.1 NZ_CP098219:1137945-1138727 [Escherichia coli]
MPNYLNWLMQNTLPGQVLLQSWLTRNGVDRKLSYLYVQNGWLRRIAHGVYCRTGREPDWVDAVYCLQTQWEKPVRVAGLT
SLALQGHAHYTEPGKPQVWLALPAYVKLPGWFAAFEQSATFITLYTSGLTVDVSSFTTELKIGDRQLAGSAPELAAYEIA
CGVPSLISFEHADALFQGGNLLSPRKLQALLRASHSIKTNRVMLYLARRNGHPYFQYLDQSGIETGTGKRQIIPGGWLEP
DYQITVPRTFKPEGVEDGSA

Nucleotide

• Length: 783 bp

Structures

Toxin

• AlphaFold DB: A0A061KTE0