Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type V Classification (family/domain) ghoTS/ghoT-GhoS
Location 518994..519503 Replicon chromosome
Accession NZ_CP098219
Organism Escherichia coli strain Z0117EC0013

Toxin (Protein)


Gene name ghoT Uniprot ID L4JJG6
Locus tag NBY13_RS02320 Protein ID WP_001173343.1
Coordinates 519330..519503 (+) Length 58 a.a.

Antitoxin (Protein)


Gene name ghoS Uniprot ID -
Locus tag NBY13_RS02315 Protein ID WP_250838132.1
Coordinates 518994..519302 (+) Length 103 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NBY13_RS02305 (517170) 517170..517442 + 273 WP_000405643.1 GNAT family N-acetyltransferase -
NBY13_RS02310 (517769) 517769..518997 + 1229 WP_102384962.1 IS3 family transposase -
NBY13_RS02315 (518994) 518994..519302 + 309 WP_250838132.1 type V toxin-antitoxin system endoribonuclease antitoxin GhoS Antitoxin
NBY13_RS02320 (519330) 519330..519503 + 174 WP_001173343.1 type V toxin-antitoxin system toxin GhoT Toxin
NBY13_RS02325 (519622) 519622..521139 - 1518 WP_000003806.1 lysine--tRNA ligase -
NBY13_RS02330 (521376) 521376..522833 - 1458 WP_000856826.1 dipeptide/tripeptide permease DtpC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 501987..528357 26370


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin GhoT/OrtT

(4-57)

Antitoxin

Endoribonuclease antitoxin GhoS

(9-98)


Sequences

Toxin        


Download         Length: 58 a.a.        Molecular weight: 6555.06 Da        Isoelectric Point: 10.2288

>T247179 WP_001173343.1 NZ_CP098219:519330-519503 [Escherichia coli]
MALFSKILIFYVIGVNISFVIIWFISHEKTHIRLLSAFLVGITWPMSLPVALLFSLF

Download         Length: 174 bp

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 11762.27 Da        Isoelectric Point: 4.1705

>AT247179 WP_250838132.1 NZ_CP098219:518994-519302 [Escherichia coli]
IGANPEGKNKFNTYVVSFDYPSSYSSVFLRLRSLMYDMNFSSIVADEYGIPRQLNENSFAITTSLAASEIEDLIRLKCLD
LPDIDFDLSIMTVDDYFRQFYK

Download         Length: 309 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9QI41

Antitoxin

Source ID Structure

References