Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 5021618..5022453 Replicon chromosome
Accession NZ_CP098217
Organism Escherichia coli strain Z0117EC0032

Toxin (Protein)


Gene name yeeV Uniprot ID -
Locus tag NBY14_RS23980 Protein ID WP_001565141.1
Coordinates 5022076..5022453 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag NBY14_RS23975 Protein ID WP_001565140.1
Coordinates 5021618..5021986 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NBY14_RS23955 (5019366) 5019366..5020184 + 819 WP_021536653.1 DUF932 domain-containing protein -
NBY14_RS23960 (5020276) 5020276..5020761 + 486 WP_001565139.1 antirestriction protein -
NBY14_RS23965 (5020777) 5020777..5021253 + 477 WP_001186724.1 RadC family protein -
NBY14_RS23970 (5021322) 5021322..5021543 + 222 WP_000692303.1 DUF987 domain-containing protein -
NBY14_RS23975 (5021618) 5021618..5021986 + 369 WP_001565140.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
NBY14_RS23980 (5022076) 5022076..5022453 + 378 WP_001565141.1 TA system toxin CbtA family protein Toxin
NBY14_RS23985 (5022450) 5022450..5022938 + 489 WP_001565142.1 DUF5983 family protein -
NBY14_RS23990 (5022950) 5022950..5023147 + 198 WP_000839256.1 DUF957 domain-containing protein -
NBY14_RS23995 (5023232) 5023232..5024074 + 843 WP_001565143.1 DUF4942 domain-containing protein -
NBY14_RS24000 (5024258) 5024258..5024463 + 206 Protein_4692 RhuM family protein -
NBY14_RS24005 (5024868) 5024868..5026052 + 1185 WP_001172876.1 sugar efflux transporter -
NBY14_RS24010 (5026163) 5026163..5027086 + 924 WP_000535949.1 carboxylate/amino acid/amine transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(19-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14246.27 Da        Isoelectric Point: 7.2920

>T247178 WP_001565141.1 NZ_CP098217:5022076-5022453 [Escherichia coli]
MKTLPDTHVREASRCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SICPRSQLINSIDILRARRATGLMTRDNYRMVNNITQGKHPEAQQ

Download         Length: 378 bp

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13604.41 Da        Isoelectric Point: 6.7389

>AT247178 WP_001565140.1 NZ_CP098217:5021618-5021986 [Escherichia coli]
VSDTLPGTTHPDDNHDRLWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSNADAYHLDQAFALLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPETKK

Download         Length: 369 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References