Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 4891699..4892311 Replicon chromosome
Accession NZ_CP098217
Organism Escherichia coli strain Z0117EC0032

Toxin (Protein)


Gene name hicA Uniprot ID U9YXE2
Locus tag NBY14_RS23360 Protein ID WP_000833473.1
Coordinates 4892126..4892311 (-) Length 62 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID L4IWR9
Locus tag NBY14_RS23355 Protein ID WP_000499744.1
Coordinates 4891699..4892109 (-) Length 137 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NBY14_RS23340 (4887211) 4887211..4888026 - 816 WP_000891823.1 AraC family transcriptional regulator -
NBY14_RS23345 (4888252) 4888252..4889652 + 1401 WP_000204811.1 MFS transporter -
NBY14_RS23350 (4889663) 4889663..4891627 + 1965 WP_001551835.1 glycoside hydrolase family 127 protein -
NBY14_RS23355 (4891699) 4891699..4892109 - 411 WP_000499744.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
NBY14_RS23360 (4892126) 4892126..4892311 - 186 WP_000833473.1 type II toxin-antitoxin system HicA family toxin Toxin
NBY14_RS23365 (4892580) 4892580..4894118 - 1539 WP_001551836.1 aldehyde dehydrogenase AldB -
NBY14_RS23370 (4894319) 4894319..4895470 - 1152 WP_000741501.1 L-threonine dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-129)


Sequences

Toxin        


Download         Length: 62 a.a.        Molecular weight: 6800.89 Da        Isoelectric Point: 11.7053

>T247177 WP_000833473.1 NZ_CP098217:c4892311-4892126 [Escherichia coli]
VKSADVIAILKQHGWEHIRTRGSHHQFRHPVHPGLVTVPHPKKDIKPGTLAQIGRQAGLTF

Download         Length: 186 bp

Antitoxin


Download         Length: 137 a.a.        Molecular weight: 15241.15 Da        Isoelectric Point: 4.5486

>AT247177 WP_000499744.1 NZ_CP098217:c4892109-4891699 [Escherichia coli]
MFYPAYIHSDPDGSASGFFPDVPGCYFAGDTLDNAFQDARSALVAHFETLCEMNEELPLPGSVETHLVQRAQDFIGGQWL
LVDINMNQFEGRAERINITMPKRLLNKIDTYVRNNPDYANRSAFLAEAARRVLPGV

Download         Length: 411 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9YXE2

Antitoxin

Source ID Structure
AlphaFold DB L4IWR9

References