Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2456296..2456934 Replicon chromosome
Accession NZ_CP098217
Organism Escherichia coli strain Z0117EC0032

Toxin (Protein)


Gene name hicA Uniprot ID A0A7U9DHD1
Locus tag NBY14_RS11680 Protein ID WP_000813795.1
Coordinates 2456296..2456472 (+) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag NBY14_RS11685 Protein ID WP_076797675.1
Coordinates 2456518..2456934 (+) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NBY14_RS11660 (2451918) 2451918..2453090 - 1173 WP_231531981.1 BenE family transporter YdcO -
NBY14_RS11665 (2453182) 2453182..2453718 + 537 WP_001551089.1 DNA-binding transcriptional regulator SutR -
NBY14_RS11670 (2453791) 2453791..2455752 + 1962 WP_001551090.1 23S rRNA 5-hydroxycytidine C2501 synthase -
NBY14_RS11675 (2455844) 2455844..2456074 - 231 WP_023910283.1 YncJ family protein -
NBY14_RS11680 (2456296) 2456296..2456472 + 177 WP_000813795.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
NBY14_RS11685 (2456518) 2456518..2456934 + 417 WP_076797675.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
NBY14_RS11690 (2457013) 2457013..2458419 + 1407 WP_001551093.1 PLP-dependent aminotransferase family protein -
NBY14_RS11695 (2458664) 2458664..2459809 + 1146 WP_001551094.1 ABC transporter substrate-binding protein -
NBY14_RS11700 (2459827) 2459827..2460840 + 1014 WP_001551095.1 ABC transporter ATP-binding protein -
NBY14_RS11705 (2460841) 2460841..2461782 + 942 WP_001251315.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-65)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6747.80 Da        Isoelectric Point: 11.5666

>T247164 WP_000813795.1 NZ_CP098217:2456296-2456472 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPSEEIKEPLRKAILKQLGLS

Download         Length: 177 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15220.55 Da        Isoelectric Point: 4.7386

>AT247164 WP_076797675.1 NZ_CP098217:2456518-2456934 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPSNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9DHD1

Antitoxin

Source ID Structure

References