Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-HTH_XRE
Location 1772325..1773030 Replicon chromosome
Accession NZ_CP098217
Organism Escherichia coli strain Z0117EC0032

Toxin (Protein)


Gene name relE Uniprot ID S1F406
Locus tag NBY14_RS08245 Protein ID WP_000539521.1
Coordinates 1772644..1773030 (-) Length 129 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag NBY14_RS08240 Protein ID WP_001280945.1
Coordinates 1772325..1772654 (-) Length 110 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NBY14_RS08225 (1767482) 1767482..1768393 + 912 WP_001236042.1 glutathione ABC transporter permease GsiD -
NBY14_RS08230 (1768571) 1768571..1770919 + 2349 WP_001550886.1 EAL domain-containing protein -
NBY14_RS08235 (1770927) 1770927..1772255 + 1329 WP_001550887.1 GGDEF domain-containing protein -
NBY14_RS08240 (1772325) 1772325..1772654 - 330 WP_001280945.1 DNA-binding transcriptional regulator Antitoxin
NBY14_RS08245 (1772644) 1772644..1773030 - 387 WP_000539521.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NBY14_RS08250 (1773256) 1773256..1774581 - 1326 WP_000049367.1 30S ribosomal protein S12 methylthiotransferase RimO -
NBY14_RS08255 (1774794) 1774794..1775177 + 384 WP_000497137.1 biofilm formation regulator BssR -
NBY14_RS08260 (1775288) 1775288..1776403 + 1116 WP_000555051.1 aldose sugar dehydrogenase YliI -
NBY14_RS08265 (1776400) 1776400..1777026 - 627 WP_001295292.1 glutathione S-transferase GstB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(1-124)

Antitoxin

Cro/C1-type helix-turn-helix domain

(53-94)


Sequences

Toxin        


Download         Length: 129 a.a.        Molecular weight: 14293.45 Da        Isoelectric Point: 9.9296

>T247159 WP_000539521.1 NZ_CP098217:c1773030-1772644 [Escherichia coli]
MGVYKARRFSQSTKKLGIHDKVLMAAAEEVMQGIWEADLGSGVIKKRLPLQQGKSGGARTIIFFKSANHVFFYDGWSKSG
LSSKGTKEIEDDELAAYKKMANAFLAFSNKQIEDLIETGFLIEVKNER

Download         Length: 387 bp

Antitoxin


Download         Length: 110 a.a.        Molecular weight: 11982.08 Da        Isoelectric Point: 10.0101

>AT247159 WP_001280945.1 NZ_CP098217:c1772654-1772325 [Escherichia coli]
MSDKLQMMLEDAKELNALGLMSDSEVDAIAVMVKAREVSARIAKVKSMTGEEIKAIRTRYGMSQSVLAHTMGMSKESVSK
WERNEIKPSGPALRILNTLAIKGPEVFAK

Download         Length: 330 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829GCT6

Antitoxin

Source ID Structure

References