Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1362789..1363407 Replicon chromosome
Accession NZ_CP098217
Organism Escherichia coli strain Z0117EC0032

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag NBY14_RS06425 Protein ID WP_001291435.1
Coordinates 1362789..1363007 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag NBY14_RS06430 Protein ID WP_000344800.1
Coordinates 1363033..1363407 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NBY14_RS06390 (1358078) 1358078..1358650 + 573 WP_000779831.1 YbaY family lipoprotein -
NBY14_RS06395 (1358681) 1358681..1358992 - 312 WP_000409911.1 MGMT family protein -
NBY14_RS06405 (1359371) 1359371..1359724 + 354 WP_001550741.1 DUF1428 family protein -
NBY14_RS06410 (1359766) 1359766..1361316 - 1551 WP_001366446.1 cyclic-guanylate-specific phosphodiesterase PdeB -
NBY14_RS06415 (1361480) 1361480..1361950 - 471 WP_000136192.1 YlaC family protein -
NBY14_RS06420 (1362066) 1362066..1362617 - 552 WP_060579167.1 maltose O-acetyltransferase -
NBY14_RS06425 (1362789) 1362789..1363007 - 219 WP_001291435.1 HHA domain-containing protein Toxin
NBY14_RS06430 (1363033) 1363033..1363407 - 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
NBY14_RS06435 (1363953) 1363953..1367102 - 3150 WP_001132480.1 efflux RND transporter permease AcrB -
NBY14_RS06440 (1367125) 1367125..1368318 - 1194 WP_001295833.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T247158 WP_001291435.1 NZ_CP098217:c1363007-1362789 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT247158 WP_000344800.1 NZ_CP098217:c1363407-1363033 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References