Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 639404..639926 Replicon chromosome
Accession NZ_CP098217
Organism Escherichia coli strain Z0117EC0032

Toxin (Protein)


Gene name relE Uniprot ID A0A829L6G8
Locus tag NBY14_RS02975 Protein ID WP_001105433.1
Coordinates 639636..639926 (+) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V0SC69
Locus tag NBY14_RS02970 Protein ID WP_000212715.1
Coordinates 639404..639646 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NBY14_RS02950 (635123) 635123..636496 + 1374 WP_001522402.1 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase -
NBY14_RS02955 (636646) 636646..637197 - 552 WP_000166270.1 ribosome biogenesis factor YjgA -
NBY14_RS02960 (637291) 637291..638643 + 1353 WP_001162173.1 metalloprotease PmbA -
NBY14_RS02965 (638826) 638826..639212 + 387 WP_001232246.1 cytochrome b562 -
NBY14_RS02970 (639404) 639404..639646 + 243 WP_000212715.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
NBY14_RS02975 (639636) 639636..639926 + 291 WP_001105433.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NBY14_RS02980 (639927) 639927..640391 - 465 WP_001009182.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
NBY14_RS02985 (640571) 640571..642709 - 2139 WP_000187798.1 anaerobic ribonucleoside-triphosphate reductase -
NBY14_RS02990 (643103) 643103..644758 - 1656 WP_001550509.1 alpha,alpha-phosphotrehalase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-72)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11367.23 Da        Isoelectric Point: 10.0238

>T247155 WP_001105433.1 NZ_CP098217:639636-639926 [Escherichia coli]
MNYELAFDPRALKEWQKLGVTVREQFKKKLEDVLKRPRNPSAKLRDLPDCYKIKLRTQGYRLVYQVNDKELLVLVIAIGK
RENSAVYEDATKRLDE

Download         Length: 291 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9125.56 Da        Isoelectric Point: 5.1369

>AT247155 WP_000212715.1 NZ_CP098217:639404-639646 [Escherichia coli]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAENGRMPVKTLTVSDSEEALLRTVRERLANPQEAIKVRLDEL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829L6G8

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9H4B3

References