Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 98315..98940 Replicon plasmid pZ0117EC0036-1
Accession NZ_CP098215
Organism Escherichia coli strain Z0117EC0036

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag NBY15_RS25150 Protein ID WP_000911313.1
Coordinates 98315..98713 (-) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID V0VCB2
Locus tag NBY15_RS25155 Protein ID WP_000450520.1
Coordinates 98713..98940 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NBY15_RS25135 (94640) 94640..95137 + 498 WP_000605857.1 entry exclusion protein -
NBY15_RS25140 (95169) 95169..95900 + 732 WP_023565183.1 conjugal transfer complement resistance protein TraT -
NBY15_RS25145 (96153) 96153..98306 + 2154 WP_000009324.1 type IV conjugative transfer system coupling protein TraD -
NBY15_RS25150 (98315) 98315..98713 - 399 WP_000911313.1 type II toxin-antitoxin system VapC family toxin Toxin
NBY15_RS25155 (98713) 98713..98940 - 228 WP_000450520.1 toxin-antitoxin system antitoxin VapB Antitoxin

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid aadA5 / qacE / sul1 / mph(A) / sul2 / aph(3'')-Ib / aph(6)-Id / tet(A) / sitABCD / blaTEM-1B / aac(3)-IId / blaCTX-M-65 iucA / iucB / iucC / iucD / iutA / iroC / iroC / iroC / iroD / iroD / iroE / iroN 1..157136 157136


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(8-50)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14901.15 Da        Isoelectric Point: 7.8605

>T247148 WP_000911313.1 NZ_CP098215:c98713-98315 [Escherichia coli]
MLKFMLDTNICIFTIKNKPASVRERFNLNQGRMCISSVTLMELIYGAEKSQMPERNLAVIEGFVSRIDVLDYDAAAATHS
GQIRAELARQGRPVGPFDQMIAGHARSRGLIIVTNNTREFERVDGLRIEDWS

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8596.63 Da        Isoelectric Point: 4.7513

>AT247148 WP_000450520.1 NZ_CP098215:c98940-98713 [Escherichia coli]
METTVFFSNRSQAVRLPKAVALPENVKRVEVIAVGRTRIITPAGETWDEWFDGHNVSADFMDNREQPGMQERESF

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB V0VCB2

References