Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 4270817..4271645 Replicon chromosome
Accession NZ_CP098214
Organism Escherichia coli strain Z0117EC0036

Toxin (Protein)


Gene name yeeV Uniprot ID -
Locus tag NBY15_RS20890 Protein ID WP_021561043.1
Coordinates 4270817..4271191 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag NBY15_RS20895 Protein ID WP_024230663.1
Coordinates 4271280..4271645 (-) Length 122 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NBY15_RS20865 (4266316) 4266316..4266495 + 180 Protein_4094 peptidase -
NBY15_RS20870 (4266894) 4266894..4268930 - 2037 WP_021561045.1 hypothetical protein -
NBY15_RS20875 (4269886) 4269886..4270035 - 150 Protein_4096 hypothetical protein -
NBY15_RS20880 (4270120) 4270120..4270317 - 198 WP_024192776.1 DUF957 domain-containing protein -
NBY15_RS20885 (4270329) 4270329..4270820 - 492 WP_001598218.1 DUF5983 family protein -
NBY15_RS20890 (4270817) 4270817..4271191 - 375 WP_021561043.1 type IV toxin-antitoxin system cytoskeleton-binding toxin CbtA Toxin
NBY15_RS20895 (4271280) 4271280..4271645 - 366 WP_024230663.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
NBY15_RS20900 (4271719) 4271719..4271940 - 222 WP_000692323.1 DUF987 domain-containing protein -
NBY15_RS20905 (4272003) 4272003..4272479 - 477 WP_021561041.1 RadC family protein -
NBY15_RS20910 (4272495) 4272495..4272980 - 486 WP_000206667.1 antirestriction protein -
NBY15_RS20915 (4273073) 4273073..4273891 - 819 WP_021561040.1 DUF932 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - fimB 4260233..4305068 44835


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(17-116)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13774.74 Da        Isoelectric Point: 6.7175

>T247141 WP_021561043.1 NZ_CP098214:c4271191-4270817 [Escherichia coli]
MKTLPVLPGQAASSRLSPVEIWQILLSRLLDQHYGLTLDDTPFADERVIEQHIEAGISLCDAVNFLVEKYTLVRTDQPGF
SAGASSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPEAK

Download         Length: 375 bp

Antitoxin


Download         Length: 122 a.a.        Molecular weight: 13494.31 Da        Isoelectric Point: 6.4648

>AT247141 WP_024230663.1 NZ_CP098214:c4271645-4271280 [Escherichia coli]
VSDTLPGTTHPDNNNRPWWGLPCTVMPCFGARLVQEGNRLHYLADRAGIRGRFSDADSYHLDQAFPLLMKQLELMLTSGE
LSPRYQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPETKT

Download         Length: 366 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References