Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3659690..3660308 Replicon chromosome
Accession NZ_CP098214
Organism Escherichia coli strain Z0117EC0036

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag NBY15_RS18025 Protein ID WP_001291435.1
Coordinates 3660090..3660308 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag NBY15_RS18020 Protein ID WP_000344800.1
Coordinates 3659690..3660064 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NBY15_RS18010 (3654780) 3654780..3655973 + 1194 WP_001295833.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
NBY15_RS18015 (3655996) 3655996..3659145 + 3150 WP_001132480.1 efflux RND transporter permease AcrB -
NBY15_RS18020 (3659690) 3659690..3660064 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
NBY15_RS18025 (3660090) 3660090..3660308 + 219 WP_001291435.1 HHA domain-containing protein Toxin
NBY15_RS18030 (3660482) 3660482..3661033 + 552 WP_000102539.1 maltose O-acetyltransferase -
NBY15_RS18035 (3661149) 3661149..3661619 + 471 WP_000136192.1 YlaC family protein -
NBY15_RS18040 (3661783) 3661783..3663333 + 1551 WP_021560766.1 cyclic-guanylate-specific phosphodiesterase PdeB -
NBY15_RS18045 (3663375) 3663375..3663728 - 354 WP_000878138.1 DUF1428 family protein -
NBY15_RS18055 (3664107) 3664107..3664418 + 312 WP_000409908.1 MGMT family protein -
NBY15_RS18060 (3664449) 3664449..3665021 - 573 WP_000779830.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T247134 WP_001291435.1 NZ_CP098214:3660090-3660308 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT247134 WP_000344800.1 NZ_CP098214:3659690-3660064 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References