Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 1039895..1040549 Replicon chromosome
Accession NZ_CP098214
Organism Escherichia coli strain Z0117EC0036

Toxin (Protein)


Gene name cptA Uniprot ID S1PAM6
Locus tag NBY15_RS05305 Protein ID WP_000244781.1
Coordinates 1040142..1040549 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag NBY15_RS05300 Protein ID WP_000354046.1
Coordinates 1039895..1040161 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NBY15_RS05280 (1035983) 1035983..1037416 - 1434 Protein_1043 6-phospho-beta-glucosidase BglA -
NBY15_RS05285 (1037461) 1037461..1037772 + 312 WP_001182956.1 N(4)-acetylcytidine aminohydrolase -
NBY15_RS05290 (1037936) 1037936..1038595 + 660 WP_000250274.1 hemolysin III family protein -
NBY15_RS05295 (1038672) 1038672..1039652 - 981 WP_000886078.1 tRNA-modifying protein YgfZ -
NBY15_RS05300 (1039895) 1039895..1040161 + 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
NBY15_RS05305 (1040142) 1040142..1040549 + 408 WP_000244781.1 protein YgfX Toxin
NBY15_RS05310 (1040589) 1040589..1041110 - 522 WP_001055874.1 flavodoxin FldB -
NBY15_RS05315 (1041222) 1041222..1042118 + 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
NBY15_RS05320 (1042143) 1042143..1042853 + 711 WP_000715230.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
NBY15_RS05325 (1042859) 1042859..1044592 + 1734 WP_021521009.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16061.99 Da        Isoelectric Point: 11.5202

>T247123 WP_000244781.1 NZ_CP098214:1040142-1040549 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDSGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT247123 WP_000354046.1 NZ_CP098214:1039895-1040161 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PAM6

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References