Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type V Classification (family/domain) ghoTS/ghoT-GhoS
Location 4405518..4406015 Replicon chromosome
Accession NZ_CP098211
Organism Escherichia coli strain Z0117EC0040

Toxin (Protein)


Gene name ghoT Uniprot ID L4JJG6
Locus tag NBY16_RS21290 Protein ID WP_001173343.1
Coordinates 4405518..4405691 (-) Length 58 a.a.

Antitoxin (Protein)


Gene name ghoS Uniprot ID L4JK92
Locus tag NBY16_RS21295 Protein ID WP_000398619.1
Coordinates 4405719..4406015 (-) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NBY16_RS21280 (4402188) 4402188..4403645 + 1458 WP_000856841.1 dipeptide/tripeptide permease DtpC -
NBY16_RS21285 (4403882) 4403882..4405399 + 1518 WP_001295087.1 lysine--tRNA ligase -
NBY16_RS21290 (4405518) 4405518..4405691 - 174 WP_001173343.1 type V toxin-antitoxin system toxin GhoT Toxin
NBY16_RS21295 (4405719) 4405719..4406015 - 297 WP_000398619.1 type V toxin-antitoxin system endoribonuclease antitoxin GhoS Antitoxin
NBY16_RS21300 (4406242) 4406242..4406514 - 273 WP_000405649.1 GNAT family N-acetyltransferase -
NBY16_RS21305 (4406526) 4406526..4406756 - 231 WP_000371700.1 4Fe-4S mono-cluster protein YjdI -
NBY16_RS21310 (4406937) 4406937..4408568 + 1632 WP_001216487.1 sensor histidine kinase -
NBY16_RS21315 (4408565) 4408565..4409284 + 720 WP_000611288.1 two-component system response regulator DcuR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin GhoT/OrtT

(4-57)

Antitoxin

Endoribonuclease antitoxin GhoS

(5-94)


Sequences

Toxin        


Download         Length: 58 a.a.        Molecular weight: 6555.06 Da        Isoelectric Point: 10.2288

>T247114 WP_001173343.1 NZ_CP098211:c4405691-4405518 [Escherichia coli]
MALFSKILIFYVIGVNISFVIIWFISHEKTHIRLLSAFLVGITWPMSLPVALLFSLF

Download         Length: 174 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11467.97 Da        Isoelectric Point: 4.1705

>AT247114 WP_000398619.1 NZ_CP098211:c4406015-4405719 [Escherichia coli]
MEGKNKFNTYVVSFDYPSSYSSVFLRLRSLMYDMNFSSIVADEYGIPRQLNENSFAITTSLAASEIEDLIRLKCLDLPDI
DFDLNIMTVDDYFRQFYK

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9QI41

Antitoxin

Source ID Structure
PDB 2LLZ
AlphaFold DB A0A7U9QBH6

References