247113

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 4301715..4302310 Replicon chromosome
Accession NZ_CP098211
Organism Escherichia coli strain Z0117EC0040

Toxin (Protein)


Gene name chpB Uniprot ID U9Y4M4
Locus tag NBY16_RS20770 Protein ID WP_000239579.1
Coordinates 4301715..4302065 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID U9Y2K1
Locus tag NBY16_RS20775 Protein ID WP_001223208.1
Coordinates 4302059..4302310 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NBY16_RS20750 (4296991) 4296991..4298013 - 1023 WP_048963592.1 ABC transporter permease -
NBY16_RS20755 (4298027) 4298027..4299529 - 1503 WP_000205793.1 sugar ABC transporter ATP-binding protein -
NBY16_RS20760 (4299839) 4299839..4300795 - 957 WP_000265933.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
NBY16_RS20765 (4301105) 4301105..4301635 + 531 WP_000055072.1 inorganic diphosphatase -
NBY16_RS20770 (4301715) 4301715..4302065 - 351 WP_000239579.1 endoribonuclease toxin ChpB Toxin
NBY16_RS20775 (4302059) 4302059..4302310 - 252 WP_001223208.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
NBY16_RS20780 (4302523) 4302523..4302864 - 342 WP_001219160.1 gamma-glutamylcyclotransferase -
NBY16_RS20785 (4302867) 4302867..4306646 - 3780 WP_000060896.1 autotransporter assembly complex protein TamB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12511.45 Da        Isoelectric Point: 5.6219

>T247113 WP_000239579.1 NZ_CP098211:c4302065-4301715 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLRARLAKRIGLAADEVVEEALLRLQAVVE

Download         Length: 351 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9271.58 Da        Isoelectric Point: 4.4201

>AT247113 WP_001223208.1 NZ_CP098211:c4302310-4302059 [Escherichia coli]
MRITIKRWGNSAGMVIPNIVMKELNLQPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNAAELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y8A8

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LQ26

References