Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | sanaTA/AbiEii-DUF6088 |
| Location | 4223812..4225147 | Replicon | chromosome |
| Accession | NZ_CP098211 | ||
| Organism | Escherichia coli strain Z0117EC0040 | ||
Toxin (Protein)
| Gene name | sanaT | Uniprot ID | - |
| Locus tag | NBY16_RS20365 | Protein ID | WP_048963133.1 |
| Coordinates | 4223812..4224759 (-) | Length | 316 a.a. |
Antitoxin (Protein)
| Gene name | sanaA | Uniprot ID | A0A228Z6F8 |
| Locus tag | NBY16_RS20370 | Protein ID | WP_000152739.1 |
| Coordinates | 4224752..4225147 (-) | Length | 132 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| NBY16_RS20335 (4219665) | 4219665..4220381 | + | 717 | WP_001295734.1 | N-acetylneuraminic acid outer membrane channel NanC | - |
| NBY16_RS20340 (4220401) | 4220401..4221507 | + | 1107 | WP_001299704.1 | N-acetylneuraminate epimerase | - |
| NBY16_RS20345 (4221572) | 4221572..4222552 | + | 981 | WP_048963137.1 | sialate O-acetylesterase | - |
| NBY16_RS20350 (4222560) | 4222560..4223210 | - | 651 | WP_048963135.1 | HNH endonuclease | - |
| NBY16_RS20355 (4223347) | 4223347..4223490 | + | 144 | Protein_3995 | HNH endonuclease | - |
| NBY16_RS20360 (4223589) | 4223589..4223774 | + | 186 | WP_000066585.1 | hypothetical protein | - |
| NBY16_RS20365 (4223812) | 4223812..4224759 | - | 948 | WP_048963133.1 | nucleotidyl transferase AbiEii/AbiGii toxin family protein | Toxin |
| NBY16_RS20370 (4224752) | 4224752..4225147 | - | 396 | WP_000152739.1 | DUF6088 family protein | Antitoxin |
| NBY16_RS20375 (4225217) | 4225217..4226050 | - | 834 | WP_048963131.1 | DUF4942 domain-containing protein | - |
| NBY16_RS20380 (4226358) | 4226358..4227946 | + | 1589 | Protein_4000 | type I restriction-modification system subunit M | - |
| NBY16_RS20385 (4227943) | 4227943..4229133 | + | 1191 | WP_250838342.1 | restriction endonuclease subunit S | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | fimB | 4217609..4257518 | 39909 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 316 a.a. Molecular weight: 35632.80 Da Isoelectric Point: 4.8847
>T247111 WP_048963133.1 NZ_CP098211:c4224759-4223812 [Escherichia coli]
MDDLTTLFSEVADALGIESVAIVEKDHYIVELLQLLKPLVFDTHQLVFAGGTALAKSGVALNRMSEDVDIKLVPKDAFQA
LSRTQRKNTRKEIVQAVSSAIASSGVFNFDDDYPKVTRDEYRYNDIPVRYPQRVVQAPCLRPFIRLELMEAKLLEPSELR
DIHSLVTGITGKAAIVSAFPCATIISTQAEKLVAMLRRTAVVVRDVERFDDASLVRHIYDTNCIVETSHVDMSQLVDFVQ
QTIEQDIQRYGNQYPQFCASPVDELKMGLDELANNPLYEMRYQQFVSPMVYGERKITWDEAYSRFRSLALAILNA
MDDLTTLFSEVADALGIESVAIVEKDHYIVELLQLLKPLVFDTHQLVFAGGTALAKSGVALNRMSEDVDIKLVPKDAFQA
LSRTQRKNTRKEIVQAVSSAIASSGVFNFDDDYPKVTRDEYRYNDIPVRYPQRVVQAPCLRPFIRLELMEAKLLEPSELR
DIHSLVTGITGKAAIVSAFPCATIISTQAEKLVAMLRRTAVVVRDVERFDDASLVRHIYDTNCIVETSHVDMSQLVDFVQ
QTIEQDIQRYGNQYPQFCASPVDELKMGLDELANNPLYEMRYQQFVSPMVYGERKITWDEAYSRFRSLALAILNA
Download Length: 948 bp
Antitoxin
Download Length: 132 a.a. Molecular weight: 14605.90 Da Isoelectric Point: 11.6915
>AT247111 WP_000152739.1 NZ_CP098211:c4225147-4224752 [Escherichia coli]
MTIKARIQSRLKRSKRYVFTRDDFKDIAGYDQVGRVLRDLVREGQLLKVGYGVYTKARRNGITGKVMPAAPGGSSAVIVE
TLERLKVRYRFAGATQAYNSGTSTQIPASPEIKTPRRFKRVLSVGNSRLNG
MTIKARIQSRLKRSKRYVFTRDDFKDIAGYDQVGRVLRDLVREGQLLKVGYGVYTKARRNGITGKVMPAAPGGSSAVIVE
TLERLKVRYRFAGATQAYNSGTSTQIPASPEIKTPRRFKRVLSVGNSRLNG
Download Length: 396 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|