247109

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) itaRT/DUF1778(antitoxin)
Location 3591814..3592651 Replicon chromosome
Accession NZ_CP098211
Organism Escherichia coli strain Z0117EC0040

Toxin (Protein)


Gene name itaT Uniprot ID Q3Z4X7
Locus tag NBY16_RS17325 Protein ID WP_000227784.1
Coordinates 3592109..3592651 (+) Length 181 a.a.

Antitoxin (Protein)


Gene name itaR Uniprot ID I2UQS9
Locus tag NBY16_RS17320 Protein ID WP_001297137.1
Coordinates 3591814..3592125 (+) Length 104 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NBY16_RS17295 (3586834) 3586834..3587781 + 948 WP_001239441.1 cytochrome o ubiquinol oxidase subunit II -
NBY16_RS17300 (3587803) 3587803..3589794 + 1992 WP_000467180.1 cytochrome o ubiquinol oxidase subunit I -
NBY16_RS17305 (3589784) 3589784..3590398 + 615 WP_000179819.1 cytochrome o ubiquinol oxidase subunit III -
NBY16_RS17310 (3590398) 3590398..3590727 + 330 WP_000019869.1 cytochrome o ubiquinol oxidase subunit IV -
NBY16_RS17315 (3590739) 3590739..3591629 + 891 WP_000971336.1 heme o synthase -
NBY16_RS17320 (3591814) 3591814..3592125 + 312 WP_001297137.1 DUF1778 domain-containing protein Antitoxin
NBY16_RS17325 (3592109) 3592109..3592651 + 543 WP_000227784.1 GNAT family N-acetyltransferase Toxin
NBY16_RS17330 (3592707) 3592707..3593642 - 936 WP_001368479.1 tetratricopeptide repeat protein -
NBY16_RS17335 (3594050) 3594050..3595414 + 1365 WP_001000960.1 MFS transporter -
NBY16_RS17340 (3595542) 3595542..3596033 - 492 WP_001138904.1 nucleotide binding protein YajQ -
NBY16_RS17345 (3596201) 3596201..3597112 + 912 WP_000705865.1 2-dehydropantoate 2-reductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(68-156)

Antitoxin

Vibrio phage ICP1, Orf50

(14-97)


Sequences

Toxin        


Download         Length: 181 a.a.        Molecular weight: 19805.02 Da        Isoelectric Point: 8.3395

>T247109 WP_000227784.1 NZ_CP098211:3592109-3592651 [Escherichia coli]
MVDKHEEITLPIVLSCNYQSDITYPGQKQFDCGNPVIDKFVRASLKKSVRNSDCAAKALIDRQSGELIGICTFTAYSLEK
QRVSGVLQGSQPSEIGVVRLVMLGVARKYQKRGFGQDLLCDFFEHVKIIHQALPIKGVYLDADPAAINFYARLGFVQLSA
TPNAFGAVPMFLAIQHILAA

Download         Length: 543 bp

Antitoxin


Download         Length: 104 a.a.        Molecular weight: 11358.04 Da        Isoelectric Point: 10.4825

>AT247109 WP_001297137.1 NZ_CP098211:3591814-3592125 [Escherichia coli]
MPGKTATLPDVDKTLKNARVELKTSPDAKNKLREAAQAVGVDLSAFILSAAMERAESVLDNQRRRELSNQSWELMNQLIA
EPAQPTLALKALMKRKNSDGRQA

Download         Length: 312 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7BYY

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0Y6B3

References