247108

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3557736..3558354 Replicon chromosome
Accession NZ_CP098211
Organism Escherichia coli strain Z0117EC0040

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag NBY16_RS17155 Protein ID WP_001291435.1
Coordinates 3558136..3558354 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag NBY16_RS17150 Protein ID WP_000344800.1
Coordinates 3557736..3558110 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NBY16_RS17140 (3552825) 3552825..3554018 + 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
NBY16_RS17145 (3554041) 3554041..3557190 + 3150 WP_001132469.1 efflux RND transporter permease AcrB -
NBY16_RS17150 (3557736) 3557736..3558110 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
NBY16_RS17155 (3558136) 3558136..3558354 + 219 WP_001291435.1 HHA domain-containing protein Toxin
NBY16_RS17160 (3558526) 3558526..3559077 + 552 WP_000102564.1 maltose O-acetyltransferase -
NBY16_RS17165 (3559193) 3559193..3559663 + 471 WP_000136192.1 YlaC family protein -
NBY16_RS17170 (3559827) 3559827..3561376 + 1550 Protein_3369 cyclic-guanylate-specific phosphodiesterase PdeB -
NBY16_RS17175 (3561418) 3561418..3561771 - 354 WP_000878141.1 DUF1428 family protein -
NBY16_RS17185 (3562150) 3562150..3562461 + 312 WP_000409911.1 MGMT family protein -
NBY16_RS17190 (3562492) 3562492..3563064 - 573 WP_000779826.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T247108 WP_001291435.1 NZ_CP098211:3558136-3558354 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT247108 WP_000344800.1 NZ_CP098211:3557736-3558110 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References